The accompanying music video, however, is a typically wild entry from the musician, as she finds herself at the centre of police chase, driving straight through the middle of a strip club, filled with priests, and a shooting range occupied by children firing off rounds.
Co-written by Cyrus and Ronson, alongside Ilsey Juber, Thomas Brenneck, The Picard Brothers and Conor Rayne Syzmanski, the track will feature on Ronson's forthcoming album, which is set for release next year.
The pair are set to perform the single on the 15 December episode of Saturday Night Live.
Cyrus recently wiped her Instagram account in preparation for her new musical era, with "Nothing Breaks Like a Heart" marking Cyrus's first single since the release of her sixth album Younger Now last year.
Ronson recently worked with Lady Gaga on her album Joanne, and the track "Shallow" from this year's A Star is Born. He also collaborated with Dua Lipa on "Electricity".
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