The veteran broadcaster is a fixture of the BBC’s Westminster coverage but stepped down from his long-running show This Week earlier this year.
The new 30-minute programme is set to air at 7pm every Wednesday, a spokesperson for the BBC said.
Neil said: “The autumn of 2019 is destined to be one of the most intriguing and significant in British politics for at least a generation.
“I’m delighted to be fronting a weekly show in prime time on BBC Two that will be on top of the story, whatever direction it takes.”
Fran Unsworth, director of BBC News, said: “Andrew’s one of the best political journalists in the UK, and we’re thrilled he’ll be on our screens for a prime-time BBC Two series.
“Andrew’s special programme with the Conservative leadership candidates was hailed as a masterclass of political interviewing.
“As Britain moves towards the Brexit deadline, this show will be a must-watch for anyone who wants to understand what’s going on.”
Neil will continue to present Politics Live on BBC Two every Thursday lunchtime, the broadcaster said.
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