In the revival of the show, which will air on Disney+, Lizzie is a 30-year-old millennial navigating life in Manhattan.
The original series was one of the Disney Channel’s biggest hits and spawned a spin-off movie in 2003.
As with the Noughties show, the reboot will include an animated version of a young Lizzie who gives revealing commentary on what she is really thinking.
Duff shared an Instagram picture of herself on the first day of production, with the caption: “Happy first LIZZIE day!!!!! NYC…..cue the rain.”
Disney+ shared a second photo showing Duff holding a stuffed alpaca.
“Alpaca your bags!” the post was captioned. “Lizzie McGuire, an original series coming soon to #DisneyPlus, is heading to the Big Apple for the next chapter in Lizzie’s story.”
Original cast members Hallie Todd, Robert Carradine and Jake Thomas are reprising their roles as Jo, Sam and Matt McGuire.
Duff is also a series regular on the comedy show Younger, which was recently renewed for a seventh season.
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