Fans on social media have claimed a major spoiler is hidden in the name of the show's lead character, played by actor Mehdi Dehbi.
The political thriller series is about the sudden, mysterious appearance of a young man in Syria – who claims he was sent to Earth by his father for a special mission – being investigated by CIA officer.
The trailer for the show was shared by Netflix this week, with the caption reading: "Who do you think he is?"
However, Muslims on Twitter have pointed out that the mysterious man is called "Al-Masih".
In Islamic eschatology, Al-Masih ad-Dajjal is an evil figure comparable to the Antichrist – whose name translates to "the false messiah, liar, the deceiver" in Arabic.
Twitter user @frankoceanhafiz tweeted: "Crying @ the fact that Muslims figured out the twist ending of the Netflix 'Messiah' show b/c they LITERALLY NAMED THE CHARACTER DAJJAL."
In response, one Twitter user wrote: "Goes to show you that english speakers also dont look into the meaning or context of the concepts they use - that they borrow these concepts merely because theyre 'exotic' to other english speakers, meant to entertain an audience of english speakers and probs no one else (sic)."
Messiah has received a considerable amount of hype ahead of its release in 2020. Viewers will be able to watch it on Netflix from 1 January.
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