Christina Applegate seen for first time since diagnosis – what is MS?

The Anchorman actor revealed that she had multiple sclerosis in August 2021.

Christina Applegate (Richard Shotwell/Invision/AP) (AP)

Christina Applegate has made her first public appearance since sharing that she had been diagnosed with multiple sclerosis (MS), as she was honoured with a star on the Hollywood Walk of Fame.

The Emmy award-winning actress, who has starred in Dead to Me and the Anchorman films, became emotional during an acceptance speech in Los Angeles, saying: “I’ve had a really interesting life… this day means more to me than you could possibly imagine,” adding that she couldn’t “stand for long”.

Applegate also paid tribute to her daughter. “I’m blessed every day that I get to wake up and take you to school. You are my everything… thank you for standing by me through all of this,” she said.

She shared the news of her MS diagnosis in August 2021, describing it as a “strange journey”. Around 130,000 people in the UK have MS, a lifelong neurological condition where the immune system attacks the nervous system, causing a wide range of symptoms.

Despite the wealth of information available about MS, it’s often misunderstood, which can be frustrating for someone who has been diagnosed.

Here are a few things to know about the condition and how it can impact daily life.

1. It’s an autoimmune disease

The cells in our nervous system are covered in a protective fatty protein layer called the myelin sheath.

In MS, the immune system (which normally protects us from bugs and viruses) mistakenly attacks the nerve cells, damaging the protective sheath and triggering a process called demyelination.

Because of this process, MS disrupts the ‘messages’ travelling along nerve fibres to the brain, causing them to slow down, become distorted, or not get through at all.

2. There are many different symptoms

MS affects the brain and spinal cord and so can cause a wide range of symptoms that vary from person to person. In some cases, it can cause serious disability, although in others it can occasionally be mild.

The main symptoms include fatigue, limb weakness, difficulty walking, pain, vision problems, numbness and tingling in the body, problems with balance and issues with controlling the bladder.

Symptoms may come and go, or they can gradually get worse over time, depending on the type of MS you have. There are three types: relapsing remitting (RRMS), primary progressive (PPMS) and secondary progressive (SPMS).

Around 85% of people with MS are diagnosed with the first, RRMS, the MS Society UK say – where you have relapses followed by recovery. PPMS is usually diagnosed in people in their 40s,  and for anyone with SPMS symptoms get steadily worse – but thanks to improved treatments fewer people are likely to get to this stage.

3. People are usually diagnosed young

MS is most commonly diagnosed in people in their 20s and 30s, and it’s the most common cause of disability in younger adults.

That said, it can develop at any age, and statistics show that it’s as much as four times more common in women than men.

4. Treatment has radically improved the outlook for people with MS

Although there is no cure for MS, advancements in treatment have meant that while living with the symptoms can be difficult, it is much more manageable than it once was, and individuals have a better overall quality of life.

The NHS say that the average life expectancy for people with MS is around five to 10 years lower than average, but the gap appears to be getting smaller as therapies aiming to treat progressive MS continue to be researched.

Charities like MS Society and MS Trust have more advice, support and information for anyone who is affected by MS, or if you simply want to know more about the condition.