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Home-brewed heroin could soon become a reality

Heroin could soon be brewed at home in a similar way to beer

Tuesday 19 May 2015 14:13 BST

(Getty Images)

Scientists are warning that ‘home-brewed heroin’ could become a reality following the creation of a genetically modified yeast strain that can be used to convert sugar into opiates.

Experts fear criminal organisations could gain access to the technology, which would allow them to abandon opium poppy farms and replace them with local morphine “breweries”, making production for their illicit trade easier.

A team at the University of California, in Berkeley, discovered a missing link in the process of converting sugar to a chemical that precedes morphine. Researchers have been attempting to engineer the DNA of yeast to mimic poppies in order to create less expensive and addictive painkillers for over a decade.

The aim of this research was to open up new avenues for the production of therapeutic medicines.

Christopher Voight of the Massachusetts Institute of Technology, who was not involved in the research, said it will soon be possible to "home-brew" opiates.

Fears about the implications of this are detailed in the journal Nature Chemical Biology, while a scientific paper describing key stages in the process of producing opiates from sugar-fed yeast appears in a sister publication.

Drug addiction, overdoses, and a very brief history of Heroin

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1/14Drug addiction, overdoses, and a very brief history of Heroin

Drug addiction, overdoses, and a very brief history of Heroin

Heroin – the chemical name for which is diacetylmorphine – was originally synthesized by British chemist C.R.Alder Wright (pictured overleaf) in 1874, by adding two acetyl groups to the molecule morphine, which is naturally found in the opium poppy.

Drug addiction, overdoses, and a very brief history of Heroin

Bayer, the German pharmaceutical company behind Alka-Seltzer and Aspirin, bought the rights to diacetylmorphine, marketing it under the name “Heroin” in 1895 because early testers said that it made them feel “heroisch” or “heroic”.

Drug addiction, overdoses, and a very brief history of Heroin

By 1898, it was ready for mass marketing. It was originally sold as an over-the-counter cough suppressant that didn’t have problematic side effects, like addiction (the irony) - while alternative treatments morphine and codeine did. This was before they realised that, when taken into the body, it actually converts into morphine, and is ferociously addictive. Thus defeating the object and defining what was to become a historically embarrassing moment for the company in later years.

Drug addiction, overdoses, and a very brief history of Heroin

By 1899 Bayer was producing a ton of Heroin and exporting the drug to 23 countries, while free samples sent to doctors and studies appeared in medical journals. It was also around this time that early reports of addiction began to surface. The company wisely released Aspirin this year, which would go on to become one of the most popular and widely used pain relief drugs in the world.

Drug addiction, overdoses, and a very brief history of Heroin

US medicines containing heroin were available over the counter from 1907, after the American Medical Association gave it its stamp of approval.

Drug addiction, overdoses, and a very brief history of Heroin

As Heroin dependency became a torrent and overdoses began to be reported, Heroin was made illegal to obtain without a prescription from a doctor in the US in 1914. Bayer lost some of its trademark rights to Heroin and Aspirin under the Treaty Of Versailles in 1919, after the German defeat in World War I.

Drug addiction, overdoses, and a very brief history of Heroin

In the early 1920s, a number of addicted users in New York supported themselves by collecting and selling scrap metal retrieved from industrial dumps. It was from this that the label “junkies” was born. The behavior of Heroin addicts was soon, however, to cause a concern to the public and the authorities. In 1924, it became completely illegal, and doctors were told they could no longer prescribe the drug.

Drug addiction, overdoses, and a very brief history of Heroin

By this point, Heroin had become popular among creative industries. Pictured left is famed actress Jeanne Eagels, who died of a Heroin overdose in 1929. Its outlawed use had pushed manufacturers underground, and the purity of the product illegal traders now used varied in quality.

Drug addiction, overdoses, and a very brief history of Heroin

In the UK, the Rolleston Committee Report in 1926, illegal Heroin dealers were prosecuted, but doctors could prescribe diacetylmorphine to users when they were withdrawing from it, if it would cause harm or severe distress to the patient to go without it. This would be the law until 1959 when the number of diacetylmorphine addicts doubled every 16 months between 1959 and 1968.

Drug addiction, overdoses, and a very brief history of Heroin

The Brain Committee recommended that only selected, specially approved doctors at specialized centres were allowed to prescribe diacetylmorphine to users in 1964. The law was further restricted in 1968, and by the 1970s, the emphasis shifted to encouraging abstinence and the use of substitute methadone.

Drug addiction, overdoses, and a very brief history of Heroin

In the 1980s, the UK experienced a surge in Heroin supply because of a sudden cheap influx from Pakistan (the main supplier had been – and is now – Afghanistan). Cues from popular culture – and a social downtown caused by the economic and industrial crisis in the late 1970s – created the perfect environment for the Trainspotting generation.

Drug addiction, overdoses, and a very brief history of Heroin

In the 1990s, Heroin use was again popularized by the rise of grunge and Britpop, while the emergence of ‘the waif’ in fashion, of which Kate Moss is often cited as the originator, would give rise to the term ‘Heroin chic’. In 1994, the Swiss began to trial a diamorphine maintenance program for users who had failed multiple withdrawal programs. It aimed to maintain the health of the user, by discouraging the use of illicit street Heroin. It was deemed a success.

Drug addiction, overdoses, and a very brief history of Heroin

Today, the largest producer of opium, needed to create Heroin is Afghanistan. This is closely followed by Mexico, who increased their rate of production sixfold between 2007 and 2011. Diacetylmorphine is a controlled, Class A substance in the UK, but continues to be used in palliative care for the treatment of acute pain, such as in severe physical trauma, post-surgical and chronic pain, as well as relieving sufferers of terminal illnesses.

Drug addiction, overdoses, and a very brief history of Heroin

Key figures continue to campaign for greater sympathies and better treatment of Heroin addicts as they attempt to rehabilitate themselves and re-enter society. Russell Brand’s Give it Up Fund, run in conjunction with Comic Relief, aims to provide financial aid to help people remain free from substance abuse by setting up support groups. "It's integral that people entering a life of abstinence after the chaos of addiction have stability, support and a role to play in the wider community," he said.

Professor Tania Bubela, from the School of Public Health at the University of Alberta, Canada, warned: “In principle, anyone with access to the yeast strain and basic skills in fermentation could grow morphine-producing yeast using a home-brew kit or beer-making."

The US and Canadian team has expressed their own concerns about how dangerous the technology could be and called for strict regulations in order to thwart the potential for abuse.

Lead author US bioengineer Dr John Dueber, from the University of California, told Wired that at the moment someone would need at least a background in synthetic biology and genetics to produce the right kind of yeast.

“It is not an imminent threat," he said. "But if a strain made for licit purposes got out, then all that would be required is knowledge of brewing beer to ferment it into morphine.”

Additional reporting by agencies

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