As the resident culture expert on Queer Eye, Brown has gained worldwide fame for the sage advice he gives participants of the Netflix self-improvement show.
For his podcast, which will be titled Karamo, the reality television personality will ask listeners to call in and ask questions about various issues that they're facing in their lives.
The 38-year-old will also provide guidance on air about how they can overcome their struggles.
Many of Brown's fans have expressed excitement over the prospect of receiving counsel from him.
"Being able to chat with you is quite literally a dream come true," one of his Twitter followers commented.
"This is so thoughtful! Thank you for expanding your gift."
Another Twitter user called Brown as a US "national treasure" in response to the news.
The podcast is due to launch on audio platform Luminary at some point in the first half of 2019.
Brown isn't the only one of the Queer Eye roster to have his own podcast.
The show's grooming expert, Jonathan Van Ness, launched his audio series Getting Curious with Jonathan Van Ness in 2015.
Described as a "weekly exploration of all the things", the podcast has covered a variety of topics including activism, relationships and mental health.
Van Ness invited Brown onto the podcast in May 2018.
The co-stars discussed a variety of topics, including Brown's childhood, gay rights, school shootings and their shared experiences on Queer Eye.
"Awww... I loved being on @jvn podcast. It was such a great time," Brown tweeted following the release of the Getting Curious episode.
The broadcaster recalled how cocaine became an "escape" for him during a "low point" of his life, explaining that he would use early in the morning and in the evening on a daily basis.
"I had to forgive myself, because going through that allows me to talk to people who have addictions and say, ‘I know what you’re going through’," he said.
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