Monkey-pig hybrids created by Chinese scientists

Researchers hope to use chimera animals to help grow human organs for transplantation

Shaun Lintern
Health Correspondent
Saturday 07 December 2019 12:14 GMT
Monkey-pig hybrids created by Chinese scientists

Chinese scientists have successfully bred monkey-pig hybrids as part of research into the growth of human organs for transplantation in animals.

Although the two chimera piglets died within a week of being born, both were found to have DNA from macaque monkeys in their heart, liver, spleen, lung and skin.

They were bred from more than 4,000 embryos which were implanted into a sow using IVF, according to the New Scientist.

A team from the State Key Laboratory of Stem Cell and Reproductive Biology in Beijing genetically modified monkey cells to produce a fluorescent protein allowing the researchers to track the cells and descendant cells.

These modified cells were injected into the pig embryos five days after fertilisation.

Ten piglets were born, of which two were chimeras.

The monkey cells made up only one in 1,000 and one in 10,000 of the remaining pig cells.

The scientists are aiming to repeat the experiments to create healthy animals with higher concentrations of monkey DNA and to eventually reproduce an animal with an organ containing only monkey DNA.

The research paper, published in Protein and Cell, said the results brought the team “one step closer to producing tissue-specific functional cells and organs in a large animal model.”

This is not the first time hybrid animals have been created. In 2010, a team at Stanford University in California, created mice with a rat pancreas.

In 2017, researchers at the Salk Institute in California created pig-human chimeras with around one in 100,000 cells being human. The embryos were destroyed within a month.

According to the NHS Blood and Transplant organisation, more than 6,000 patients are currently on the waiting list for organs in the UK.

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