Libby Squire was last seen getting into a taxi outside the Welly Club, in Hull, at about 11pm on Thursday.
Police believe the Hull University student got out of the vehicle near her home on Wellesley Avenue a short while later, however CCTV captured her on Beverley Road at about 11.45pm and she hasn’t been seen or heard from since.
Ms Squire’s family said her disappearance is completely out of character and described her as a “very thoughtful and caring young woman who puts others before herself”.
Superintendent Simon Gawthorpe, of Humberside Police, said police were “extremely concerned” for Ms Squire’s welfare.
He said: “[Libby] was last seen on CCTV on Beverley Road close to the junction with Hayworth Street at around 11.45pm.
“From there she may have walked in either direction down Beverley Road, or down Hayworth Street.
“Officers are out again today searching and we are hoping that Libby will turn up safe and well.
“I urge anyone who knows anything about her whereabouts to come forward and speak to us.”
Police are urging people who live in the area to check their gardens, porches, sheds and outbuildings to see if she may have taken shelter there.
Anyone with dash cam footage who was driving in the area between 11pm Thursday and 3am Friday is also asked to contact police on 101.
Police had made an earlier appeal to trace a driver who had stopped to help Ms Squire on Beverley Road, but they said he had been located.
Ms Squire’s friends also organised a search party for her on Saturday, starting from the Hull University student union building at 3pm.
The missing student is described as 5ft 7ins tall with long dark brown hair.
She was wearing a black leather jacket, black long sleeved top and a black denim skirt with lace when she disappeared.
Anyone with information should contact Humberside Police on 101 quoting log 29 01/02/19.
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