The reticulated python was seen in the early hours of Sunday morning around Lovell Road.
Police said that they had visited the area and met the reptile's owner, who confirmed the snake measured nine feet in length.
Reticulated pythons are the world's longest snake and can grow up to 31.5 feet, according to Encyclopaedia Britannica. They are not venomous.
The pythons are constrictors and kill by wrapping their body around their prey to cut off blood circulation to the brain and inhibit breathing. They are found in India, Indonesia, Phillips and Borneo.
In a tweet posted in the early hours of Sunday morning, Cambridgeshire Police wrote:
“In the early hours of this morning Officers attended the area of Lovell Rd Cambridge. Reports of a three meter snake seen in the area.
“Police have located the owner but not the Reticulated Python confirmed to be 9ft long. Any sighting please notify Cambs Police on 101.”
It comes after Cambridgeshire Police found a large orange and black striped corn snake on the loose in May.
"Road policing officers got a bit of a shock this morning when they came across thissss snake in the grass on Arbury Road in Cambridge," police said on Twitter.
The corn snake was taken to a wildlife centre in Stretham as it was though to be a lost pet.
Anyone who sees the latest snake is asked to notify police on 101.
Additional reporting by PA
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