Four of the victims were left critically wounded after gun violence spilled out onto the streets of the city’s south side in the early hours of Sunday.
The victims range in age between 16 and 48 and suffered “different and various gunshot wounds to their bodies,” according to chief of patrol Fred Waller.
The shooting stemmed from a dispute at a house party “given in memorial of a subject slain in April,” said Mr Waller.
Shots were heard around 12.30am at home in the city’s Englewood neighbourhood, before further shooting took place outside as people began spilling out of the house. More shots were then fired at another property nearby.
Chicago Police Department said two people are being questioned after one of them was arrested with a weapon, while the other being questioned was wounded.
Mr Waller said police recovered a revolver. He described the shooting as an “isolated incident”.
Police said the shooting took place on W 57th and South May Street, a residential block near a park in Englewood.
A 57-year-old resident of the neighbourhood told the Chicago Tribune that he was woken up by at least five gunshots.
Resident Terrence Daniely told ABC News-affiliate WLS: “I was awoken by the sound of, seemed like 4, 5, or 6 gunshots and it seemed pretty loud, so it seemed kind of close.
“I didn’t see any commotion when I looked out the window but then shortly after I heard the sounds of people screaming and running from a party on the street.”
Additional reporting by agencies
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