Armed policemen are reportedly keeping watch on surrounding houses and there is no ambulance at the scene.
Police said in a tweet that they have the situation under control.
German broadcaster Rbb cited a police spokesman as saying the shots were likely related to a robbery attempt at a cafe.
The area is popular among tourists, as Checkpoint Charlie was the best-known Berlin Wall crossing point during the Cold War. It is also close to multiple museums, galleries, and bars.
Additional reporting by agencies
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