Up to thirty people are missing after an avalanche covered the three-story Hotel Rigopiano, in the town of Farindola, Abruzzo, on Wednesday evening.
The civil protection agency said it is working to get emergency vehicles to the hotel, through roads covered in snow, joining initial rescue efforts overnight by alpine rescue squads.
Italian news agency Ansa quoted the head of a mountain rescue squad as saying "there are many dead."
Mountain rescue teams reached the hotel by skis around 4am (3am GMT), SKY TG24 reported.
"Around 30 people are unaccounted for, between guests and workers at the Hotel Rigopiano in Farindola," said Fabrizio Curcio, head of Italy's civil protection department.
"We're dropping our rescue units down by helicopter and they are starting to dig," said Luca Cari, a spokesman for the national fire brigades.
A spate of strong earthquakes hit central Italy on Wednesday.
Four magnitude 5.2 and higher quakes struck near the hill town of Amatrice, some 100 km (60 miles) northeast of Rome, in the space of four hours. Much of the area had already been abandoned after last year's earthquakes.
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