Manchester City and Manchester United had already qualified for the Round of 16, but City on Wednesday cemented their place as winners of Group F with victory over Hoffenheim while United's defeat against Valencia consigned them to finishing runners-up in Group H, behind Juventus.
It is the second year in a row that there will be full Premier League representation at the first knockout stage.
But when is the draw? And who are the other teams involved?
Here’s what you need to know.
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When is the draw?
The draw takes place in Nyon on Monday 17 December.
What time is the draw?
It is expected to be held at 11.00am GMT.
Manchester City are favourites for the trophy (Getty)
Where can I watch it?
The draw will be shown live by BT Sport.
If, however, you cannot watch the draw, you will be able to follow The Independent’s live blog.
How does it work?
The English clubs are flying high in Europe (Getty)
As per usual at this stage of the competition, the draw will be seeded, with group winners playing group runners-up.
No team can be drawn against another from their group stage. Teams cannot be drawn against others from their respective nation either.
The seeded group winners will play the first leg away and the second leg at home
Who has qualified?
Group winners: Borussia Dortmund, Barcelona, Bayern Munich, Juventus, Manchester City, Paris Saint-Germain, Porto and Real Madrid.
Runners-up: Ajax, Atletico Madrid, Lyon, Tottenham Hotspur, Liverpool, Manchester United, Schalke 04 and Roma.
Spurs are into the next round by the skin of their teeth (Reuters)
When will the Champions League round of 16 take place?
This year’s round of 16 matches will take place from 12 - 20 February, with the second legs following 5 - 13 March.
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