Brugge made a positive start but any hope they had of pulling off a famous victory was seriously dented when defender Simon Deli was sent off for handball in the box.
Scott McTominay added a third before half-time, with Fred rounding off the victory with two late goals.
The 6-1 aggregate victory sees United follow Wolves into the next stage of the tournament. Here are our player ratings.
Take a look at the above gallery to see how we rated Manchester United's players.
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