The La Liga giants all but wrapped up the title at the weekened as Lionel Messi and Luis Suarez got on the scoresheet in a 2-0 win over Atletico Madrid.
By way of contrast their hosts haven't played since being humbled by Wolves a week ago.
They will be quietly confident, however, with Ole Gunnar Solskjaer already having conjured a magical result in this competition with the slaying of PSG in the last-16.
Here's everything you need to know:
Manchester United did the unthinkable once in the last round, and Barca aren’t the vaunted team of a few years previous, but it’s still hard to imagine the Spanish champions in waiting leaving Old Trafford without at least one away goal.
They can be got at and there are goals to be had if United (Romelu Lukaku specifically) strap on their shooting boots – despite the brilliance of Marc-Andre Ter Stegen between the sticks – but Messi and Co. will be looking to kill the tie this week ahead of next week’s second leg.
Expect Luis Suarez to get on the scoresheet, at least once, with United perhaps giving themselves a chance ahead of the trip to the Nou Camp with one in reply. 1-3.
What time is kick-off and how can I watch it?
The game kicks off at 8pm at Old Trafford.
It will be broadcast on BT Sport 2 and BT Sport 4K UHD. For those without access to a TV it can also be live streamed online via the BT Sport website.
Manchester United: De Gea, Young, Smalling, Lindelof, Shaw, Matic, Herrera, Pogba, Lingard, Rashford, Lukaku
Barcelona: Ter Stegen, Roberto, Pique, Lenglet, Alba, Rakitic, Busquets, Vidal, Messi, Suarez, Coutinho
Manchester United 3/1
Register for free to continue reading
Registration is a free and easy way to support our truly independent journalism
By registering, you will also enjoy limited access to Premium articles, exclusive newsletters, commenting, and virtual events with our leading journalists
Already have an account? sign in
Join our new commenting forum
Join thought-provoking conversations, follow other Independent readers and see their replies