Manchester City and Wigan will replay the 2013 FA Cup final with two divisions separating them this time after the Premier League leaders were sent to the League One pacesetters in the fifth round.
The third-tier table-toppers memorably edged out a star-studded Man City side featuring Carlos Tevez, Sergio Aguero and Yaya Toure thanks to a stoppage-time goal from Ben Watson, but were relegated three days later with defeat to Arsenal and are yet to return to the Premier League, sliding into League One twice since.
While City are favourites, cross-town rivals United are also a strong bet for the cup and they will be confident of passing Huddersfield or Birmingham City in the next round, though they'll need to do so away from home.
Millwall could face Tottenham if they get past a replay with Rochdale, but that would also require Spurs to beat Newport County.
Chelsea host Hull City after beating Newcastle United on Sunday, while West Brom vs Southampton is the only tie certain to have two Premier League sides.
Brighton host fairytale-chasing Coventry City with half an eye on survival and Leicester, likely safe from relegation, face in-form Sheffield United at home.
The Blades' cross-town rivals Wednesday will be at home but they don't know yet if they'll face Notts County or Premier League basement-dwellers Swansea City.
DRAW IN FULL
Sheffield Wednesday v Notts County or Swansea
West Brom v Southampton
Chelsea v Hull
Leicester v Sheffield United
Huddersfield or Birmingham v Manchester United
Millwall or Rochdale v Newport or Tottenham
Brighton v Coventry
Wigan v Manchester City
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