The club have confirmed 21 members of the first-team bubble have tested positive, including the manager and assistant manager Juanma Lillo. Both are now isolating.
City take on Swindon Town in the third round of the FA Cup on Friday.
The club confirmed the news with a statement on Thursday.
“Pep Guardiola will miss tomorrow evening’s FA Cup trip to Swindon Town after testing positive for Covid-19,” it read. “The City manager recorded a positive test on Tuesday along with assistant Juanma Lillo. Both are now isolating, along with a number of other positive cases within the City first team bubble.
“This brings the number of those isolating for Covid related reasons amongst the group to 21. Of that number, 14 are backroom staff with seven first team players.
“Assistant coach Rodolfo Borrell will take charge of the team for the trip to Swindon.”
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