The pair played together for a year at Paris Saint-Germain, both arriving in 2001 and striking up a friendship that lasts until the present day.
They have since gone on to become top coaches – but their meeting at Stamford Bridge on Saturday will be the first time they have faced off as opposing managers.
Pochettino, 51, is 10 years older than Arteta and while they may have signed for PSG at the same time, the Arsenal boss credits the Argentinian for taking him under his wing.
“First of all, it was my first professional opportunity in Paris and we arrived at the same time and lived together in a hotel for three months,” Arteta explained.
“He was critical, has been one of the most influential people in my career. Firstly as a player, he took me under the arm and looked after me like a little child, a little brother, and he was a big part of the success I had in Paris.
“It was because of him because he really looked after me, gave me a lot of confidence and a lot of advice.
“He has been a role model for me since that day, not only when I was a player but as a manager as well, when I had to make the decision to leave playing and start my coaching career he had a big say on that and I will always be grateful.”
Arteta has been in charge of Arsenal since December 2019, just a month after Pochettino was sacked as head coach at north London rivals Tottenham.
Pochettino returned to the Premier League when he took the reins at Chelsea in May and, despite a turbulent start, Arteta feels his old colleague is starting to turn things around.
Asked if he felt Pochettino could rise to the challenge, he replied: “Yes, you can see already that something has changed very quickly.
“It’s a big game and there is a big history between the two clubs. We know the types of games we’ve played together with them in the past but this is a different one. I’ve been really impressed by Chelsea.
“I think they deserve much more than what they’ve got in the table. What Mauricio has done in a short time is phenomenal. We’ll be have to be at our best.”
Arteta also revealed the best advice Pochettino had offered after he had hung up his boots: “’Don’t go into coaching — it’s too hard’!
“That is the first thing. I knew he was going to be a coach and I followed him very closely because as a player he was already a leader.
“The way he understood the game was phenomenal. I used to have him at my back and he was constantly coaching me. Very proud of what he has done and the way he has done it through his coaching career.”
Join our commenting forum
Join thought-provoking conversations, follow other Independent readers and see their replies