The Premier League champions have been without midfielders Kevin De Bruyne, Jack Grealish and Phil Foden for recent games due to coronavirus, in the Belgian’s case, and knocks for the England pair.
De Bruyne is now out of isolation but Wednesday’s trip to Aston Villa will come too soon while Grealish and Foden are still to prove their fitness.
To add to the issues, defender Aymeric Laporte will miss the game after collecting his fifth booking of the season against West Ham on Sunday.
Manager Guardiola, whose side trail leaders Chelsea by a point, says he can ill afford any more problems heading into a difficult December.
The Spaniard said: “We are in an emergency for the intensity of the squad. We have few people. I never complain, I never miss the players who cannot play for any reason and I trust a lot the players. When one is out, another one comes in.
“But to sustain it in December – the toughest month of the year… the fact is we are in trouble because we have few players. We have just 15 or 14 players and we are in a difficult position because a lot of players play a lot of minutes.”
Grealish has missed City’s last three games after sustaining a knock on international duty earlier this month while Foden has been out for the last two.
The pair will be given fitness tests, meaning Grealish could come into the reckoning to face the club he left in a British record £100million transfer in the summer.
Guardiola said: “In the training sessions, for Jack (on Monday) was his first minutes with the team. For Phil too.
“Maybe they can play but not a lot of minutes. We will see with the doctors and physios.”
It is unclear yet when De Bruyne will be ready to return.
Guardiola said: “Kevin is back but he needs time to be fit. People who have had Covid explain that it’s draining, tiring and takes time. He is a player who needs to be fit for his top form, or he cannot show it.”
Wednesday’s game will see Guardiola come up against Steven Gerrard for the first time since the former Liverpool captain became a manager.
Gerrard has won his first two matches since leaving Rangers to take charge at Villa following the sacking of Dean Smith.
Guardiola said: “If he’s a manager in the Premier League he’s already a good manager. I don’t believe there is one single manager in the Premier League, or even the Championship, who is not good. They are of quality.”
Register for free to continue reading
Registration is a free and easy way to support our truly independent journalism
By registering, you will also enjoy limited access to Premium articles, exclusive newsletters, commenting, and virtual events with our leading journalists
Already have an account? sign in
Join our new commenting forum
Join thought-provoking conversations, follow other Independent readers and see their replies