Manchester United are in the midst of an injury crisis, with 10 first-team players currently unavailable.
The international break has been particularly unkind to Louis van Gaal, with Michael Carrick, David De Gea and Daley Blind joining the wounded within the United squad.
It's not complete doom and gloom, as five of the 10 players injured could return in time to face Arsene Wenger's side at the Emirates on Saturday, but even in a best-case scenario and those players do come back, they are not going to be at full fitness.
Here is an XI (plus captain Wayne Rooney, who is fit and will play barring injury on England duty) that are huge doubts for the crunch Premier League clash.
(4-4-2) Goalkeeper: David De Gea
The first-choice goalkeeper dislocated his finger during training for Spain, though the extent of the damage is not fully known. Has been superb for United this season, with a number of crucial saves.
Right-back: Rafael da Silva
The Brazilian has not played since the draw with Chelsea, though he could play return Arsenal. United's best option at right full-back.
Centre-back: Jonny Evans
Has had a torrid time when he has played this season, and was part of the United teams that lost to MK Dons and Leicester and drew with Burnley. Not played for two months but could also return.
Centre-back: Marcos Rojo
Dislocated his shoulder in the Manchester derby, the Argentine will definitely not play at the Emirates.
Left-back: Daley Blind
Impressed in central midfield during Carrick's absence and equally adept in central defence or left-back, where he played at the World Cup. Early indications are that he suffered knee ligament damage on Netherlands duty.
Right midfield: Jesse Lingard
Started the first game of the season against Swansea at wing back but came off after 24 minutes and hasn't returned. Not likely to come back until at least December.
Centre midfield: Michael Carrick
Pulled out of the England squad but hinted that he would only miss the two matches for Roy Hodgson's team. Has played just two matches for United this season after injury.
Centre midfield: Phil Jones
Mostly plays at the back for Van Gaal, but equally capable of playing in midfield, Jones last played in the draw with West Bromwich. Another that could return at the Emirates.
Left midfield: Ashley Young
He too last played in the draw at The Hawthorns, one of just four appearances this season. He is currently out with a groin injury with no set return date.
Striker: Radamel Falcao
The Colombian may well play at the Emirates but he continues to struggle with numerous injuries. The loan star has played just five matches this season and has just one goal for his new club.
Striker: Wayne Rooney
Barring injury on England duty, the captain will play - we were a man short of a full XI.
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