Jonny Evans will undergo a scan on his leg after leaving the King Power Stadium on crutches.
The Manchester United defender, 26, picked up the injury just before half-time as he attempted to block a shot from Leicester City striker Leonardo Ulloa.
"I do not know how bad it is, we will have to have a scan on Monday," said United manager Louis van Gaal after the shock 5-3 defeat.
Evans was forced to leave the stadium on crutches but the United boss isn't hugely worried for the game on Saturday, adding: "I think Shaw shall be fit enough to play and Rojo and Smalling can play. We can manage."
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