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Roberto Firmino left Old Trafford on crutches after picking up an injury in Liverpool's goalless draw at Manchester United .
Firmino was brought off shortly after the half-hour mark having rolled over awkwardly on his ankle while chasing the ball.
The 27-year-old had briefly attempted to play on but quickly decided he could not continue and was replaced by Daniel Sturridge.
Firmino was later seen making his way to the Liverpool team bus on crutches and is now a doubt for Wednesday's home meeting with Watford.
Jürgen Klopp , the Liverpool manager, had no information to give on the extent of the damage to Firmino's ankle in his post-match press conference.
Player ratings from Manchester United vs LiverpoolShow all 26 1 /26Player ratings from Manchester United vs Liverpool Player ratings from Manchester United vs Liverpool David de Gea - 6 Had very little to do, with Liverpool mustering just one shot on target.
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Player ratings from Manchester United vs Liverpool Ashley Young - 7 Not as impressive as Shaw on the other flank but still largely limited Mané’s attacking potential.
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Player ratings from Manchester United vs Liverpool Chris Smalling - 8 Picked up from where he left off against Chelsea. Now appears to be Solskjaer’s first-choice partner for Lindelof.
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Player ratings from Manchester United vs Liverpool Victor Lindelof - 8 Alongside Smalling, dealt with almost everything Liverpool threw at him. Helped Shaw with Salah when required.
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Player ratings from Manchester United vs Liverpool Luke Shaw - 9 One of his best displays in a United shirt. Shut down Salah, to the point where the Liverpool winger had to be substituted.
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Player ratings from Manchester United vs Liverpool Ander Herrera - N/A His usual tenacious self until he was substituted early on with a muscle problem.
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Player ratings from Manchester United vs Liverpool Paul Pogba - 7 His usual tenacious self until he was substituted early on with a muscle problem.
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Player ratings from Manchester United vs Liverpool Scott McTominay - 7 A surprise selection at the base of midfield but coped well as Liverpool failed to exploit his relative inexperience.
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Player ratings from Manchester United vs Liverpool Juan Mata - N/A Another who departed early, without much opportunity to make an impression.
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Player ratings from Manchester United vs Liverpool Marcus Rashford - 6 Clearly felt the effects of an early challenge by Henderson but soldiered on, threatening in glimpses on the break.
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Player ratings from Manchester United vs Liverpool Romelu Lukaku - 6 Fine pass to play Lingard through first half but otherwise offered little and failed to make his presence felt against Robertson on the left.
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Player ratings from Manchester United vs Liverpool Andreas Pereira - 7 Replaced Herrera. Put recent poor displays behind him with a tidy performance at short notice, having not even had time to warm up.
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Player ratings from Manchester United vs Liverpool Jesse Lingard - N/A Replaced Mata and then went off injured himself. Had United’s best chance in his 17 minutes on the field but was smothered by Alisson.
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Player ratings from Manchester United vs Liverpool Alexis Sanchez - 6 Introduced late on in the first half but ineffective.
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Player ratings from Manchester United vs Liverpool Alisson - 8 Rushed off his line brilliantly to prevent Lingard from scoring and did well when coming to collect aerial balls.
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Player ratings from Manchester United vs Liverpool James Milner - 6 Preferred at right-back over Trent Alexander-Arnold with mixed results. Did not offer as much going forward as the youngster.
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Player ratings from Manchester United vs Liverpool Virgil van Dijk - 8 Won crucial aerial battles and interceptions. Blocked a goal-bound Pogba effort in the first half.
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Player ratings from Manchester United vs Liverpool Joel Matip - 7 Largely repaid Klopp’s trust to start in the centre of defence and even ventured forward on occasion, carrying the ball into dangerous areas.
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Player ratings from Manchester United vs Liverpool Andrew Robertson - 6 Struggled to break out from left-back and overlap in the way he usually does, though managed Lukaku well.
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Player ratings from Manchester United vs Liverpool Georginio Wijnaldum 7
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Player ratings from Manchester United vs Liverpool Jordan Henderson - 6 Battled well in midfield but did not influence Liverpool’s attacking play enough. Replaced by Xherdan Shaqiri late on.
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Player ratings from Manchester United vs Liverpool Fabinho - 7 Switched play and bypassed United’s midfield with several impressive passes in the first half but could not make one count.
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Player ratings from Manchester United vs Liverpool Sadio Mane - 5 A fitful performance, only threatening in moments and sloppy in build-up play at times.
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Player ratings from Manchester United vs Liverpool Roberto Firmino - N/A The best of Liverpool’s front three until he departed on the half hour mark after rolling his ankle awkwardly.
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Player ratings from Manchester United vs Liverpool Mohamed Salah - 5 A forgettable afternoon at Old Trafford for the Egyptian, a year on from being shut out of the game by Young.
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Player ratings from Manchester United vs Liverpool Daniel Sturridge - 6 Replaced Firmino. Had little influence on the game but did register Liverpool’s only shot on target.
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Klopp nevertheless expressed his hope that Firmino would be able to recover from the problem swiftly.
"It was something with the ankle," Klopp confirmed. "Bobby said first he could carry on then showed it couldn’t work.
"But I don't know. It’s Bobby so [his recovery] will be quicker than all the others. First we need to know exactly what it is."
Firmino was one of four players to leave the Old Trafford pitch injured in a bizarre first half on Sunday.
United trio Juan Mata, Ander Herrera and Jesse Lingard all departed early with suspected hamstring injuries, while Marcus Rashford played on with an ankle problem.
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