The sides meet at the Etihad for the latest opportunity to claim bragging rights for themselves and their fans.
The last three meetings have all gone in favour of Manchester City, with the two last term ending 3-0 and 4-1 in favour of the Sky Blues.
Those victories came during a difficult campaign for Manchester United as they came to terms with the exit of Sir Alex Ferguson.
City will come into this meeting as the favourites, a position relating to those results, their league standing as well as personnel, but with Louis van Gaal at the Old Trafford helm United fans will be hoping their side can pull off a better result.
Over the years, United have certainly had the better of it, which becomes apparent in our collection of the best Manchester derbies. But City have also had their day, as have the neutrals, with this fixture throwing up some classics down the years.
Check out our guide to the best derbies below...
Manchester United v Manchester City: The greatest derby matches
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