Slaven Bilic will make two changes to the West Ham dream that drew 2-2 with Crystal Palace last weekend.
It appears as if the Hammers boss will play with either three or five at the back in an attempt to nulify the attacking threat of Arsene Wenger's Arsenal.
James Tomkins comes in for forward Emmanuel Emenike, one of three centre-backs in the team along with Winston Reid and Angelo Ogbonna.
Cheikhou Kouyate will start in midfield after his red card against Palace was rescinded, while Andy Carroll starts up front in place of Diafra Sakho who is injured.
For the visitors, Wenger has not made any changes to the team that beat Watford 4-0 last weekend.
That means Petr Cech remains on the bench with David Ospina starting in goal.
Teenager Alex Iwobi continues as one of the forwards, with both Theo Walcott and Olivier Giroud on the bench.
TEAM NEWS
West Ham United: Adrian, Tomkins, Reid, Ogbonna, Antonio, Cresswell, Noble, Kouyate, Payet, Lanzini, Carroll.
Subs: Randolph, Hendrie, Oxford, Obiang, Moses, Valencia, Emenike
Arsenal: Ospina, Bellerin, Gabriel, Koscielny, Monreal, Elneny, Coquelin, Welbeck, Sanchez, Ozil, Iwobi
Subs: Cech, Gibbs, Mertesacker, Chambers, Ramsey, Walcott, Giroud
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