Speaking on the programme, the Girls star said: “The one time I did poppers, because I love to surround myself with beautiful homosexuals, the one time I tried poppers in my early twenties, it led to me eating a whole cheesecake.
“I don’t think that’s what’s supposed to happen,” she added.
Interviewer Andy Cohen and singer Dua Lipa, who was also included in the so-called “Dua Lena” segment, seemed to doubt the veracity of Dunham’s anecdote.
“I’ve never gotten hungry from poppers,” remarked Cohen.
Dunham started trending on Twitter when one viewer posted a clip of the interview, saying: “Lena Dunham just lied on tv by saying the ‘one time she did poppers’ it ‘made her eat a whole cheesecake’ that’s not how it works girl what.
She continued: “This was [part of] a very cursed segment w Dua Lipa and Lena called “Dua Lena” and neither Andy nor Dua believed her and u could tell.”
The initial tweet received more than 75,000 likes, with many users expressing incredulity at Dunham’s claims.
As people were quick to point out, increased apetite is typically not a side effect of the party drug.
Dunham has spoken openly about her drug use in the past, including her addiction to prescription pills in the aftermath of a hysterectomy in 2017.
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