While promoting the "Travalyst" campaign – which has been launched in collaboration with travel companies including Booking.com, Ctrip, Skyscanner, TripAdvisor and Visa – the duke spoke at Amsterdam's A'dam Tower about the "responsibility" of every consumer for the environment.
"Sometimes the scale of the conservation crisis feels overwhelming and that individual actions can't make a difference," the royal said.
"I've certainly felt that – but I've learned that we cannot dismiss the idea of trying to do something, just because we can't do everything. We can all do better."
The duke continued, saying that while "no one is perfect", "we are all responsible for our own individual impact".
"The question is what we do to balance it out," Prince Harry added.
The royal cited several of the greatest environmental challenges the world is facing, including deforestation, loss of biodiversity, the excessive amount of plastic in the ocean and poaching, problems which he said "can sometimes seem too big to fix".
The Duke of Sussex's speech comes shortly after he and the Duchess of Sussex faced criticism for flying on private jets four times over the course of 11 days during the summer.
The duke did not directly reference the criticism he and the duchess received during his speech.
In a recent post shared on the royal couple's Instagram account, Prince Harry stated that he "can't wait" to introduce Meghan and Archie to South Africa.
"In just a few weeks our family will be taking its first official tour to Africa, a region of the world that over the past two decades has been a second home to me," the duke wrote in the Instagram caption.
"Our team has helped create a meaningful programme that we're so exited to share with you.
"On a personal note, I can't wait to introduce my wife and son to South Africa! We'll see all of you very soon," Prince Harry's message concluded.
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