Statins: Almost every older person should be given potentially life-saving drugs, study finds

GPs are worried they could be encouraged to prescribe the drugs to most of their patients

Andrew Griffin
Tuesday 01 August 2017 00:05 BST
Lipitor(atorvastain calcium) tablets made by Pfizer and distributed by Parke-Davis are seen November 30, 2011 in Washington, DC
Lipitor(atorvastain calcium) tablets made by Pfizer and distributed by Parke-Davis are seen November 30, 2011 in Washington, DC (Getty)

Almost every older person should be taking statins, a new study has found.

Millions of people in the UK are eligible for and would benefit from taking the cholesterol-lowering drugs, the research found.

Almost all men over 60 and women over 75 should be taking the drugs, the research found. And more than a third of people between 30 and 84 should be allowed to do so.

The sweeping findings could suggest that GPs will be asked to prescribe the drugs to the majority of their patients, leading to huge strain on doctors.

But professional groups have warned that the relationship between a patient and their doctor remains the most important, and that the physician will still make the ultimate decision on what their patients should be prescribed, despite the findings of the study.

The research looked to investigate the effects of guidance that was set by the National Institute of Health and Care Excellence (Nice) in 2014. That controversial ruling allowed many more people to receive statin therapy on the NHS, since it suggested that anyone with cardiovascular disease should be given the drug, and anyone with a more than 10 per cent chance of developing it in the next 10 years should take it too.

The latest study, published in the British Journal of General Practice, examined the algorithm endorsed by Nice for the assessment of CVD risk and compared it to data from the 2011 Health Survey for England to estimate the number of people who are eligible for statin therapy under the guidance.

"Under the guidelines, 11.8 million (37 per cent) adults in England aged 30-84 years, including almost all males over 60 years and all females over 75 years, would be eligible for statin therapy," the authors wrote.

Of these, 9.8 million would be offered the medication as a preventative measure, the researchers discovered.

They found most adults who were eligible or treated for primary prevention were in older age groups.

Just 4 per cent of men and 2 per cent of women aged 30 to 44 were deemed to be eligible to be offered the medication, but this figure increased with age.

Among men, 33 per cent of those aged 45 to 59 would be eligible according to the risk assessment tool.

This increased to 95 per cent of men aged 60 to 74 years and 100 per cent of men aged 75 to 84.

One in 10 women aged 45 to 59 would be eligible, increasing to 66 per cent of women aged 60 to 74 and 100 per cent of women aged 75 to 84.

Among the 9.8 million deemed to be at risk of CVD, the researchers said 6.3 million were eligible for treatment but not currently on statins.

Among this group there will be a projected 1.16 million cardiovascular events - including heart attacks and strokes - over the next decade, they estimated.

The authors calculated that if all these people were taking statins 290,000 of these events could be prevented.

But they added: "It is, however, unlikely that all eligible adults will receive statins.

"The 2014 Nice guidelines recommend an informed risk/benefit discussion between the physician and the patient. A treatment recommendation will therefore not necessarily lead to treatment initiation."

Professor Mark Baker, director of the centre for guidelines at Nice, said: "Heart disease and stroke are largely age-related, killing one in three of us and disabling many more.

"To make progress in the battle against heart disease and stroke, we must encourage exercise, improve our diets still further, stop smoking, and where appropriate offer statins to people at risk.

"Their use in people who have established cardiovascular disease is not controversial. Their use to prevent the development of cardiovascular disease in well people is a more recent role but is equally widespread and robustly evidence-based.

"NICE's guidance on reducing cholesterol recommends that doctors should offer statins to people with a 10 per cent risk of developing cardiovascular disease over 10 years. The purpose is to reduce further the numbers of people suffering heart attacks and strokes.

"But people, including older people, should not take statins instead of making the lifestyle adjustments that those at risk of cardiovascular disease need to make - such as stopping smoking, being more active, drinking less alcohol, eating more healthily and losing weight."

Commenting on the paper, professor Helen Stokes-Lampard, chairwoman of the Royal College of GPs, said: "Statins have been found to be highly effective drugs at preventing cardiovascular disease by reducing cholesterol levels of patients, and extensive research has shown that taking them is safe.

"But our patients should only take medication if they need to, and specifically they are at high-risk of developing conditions that statins can help prevent.

"We need to get the risk scores right. If we find that all men over 60 and all women over 75 are going to be eligible for statins with new risk scoring, regardless of any other risk factor, then it should ring alarm bells - because it is not clear that every 60 year old man or 75 year old woman is going to benefit from statin therapy.

"As with any drug, taking statin medication has potential side-effects, and taking any medication long term is a substantial undertaking for patients.

"Many don't want to take statins once they have learned all the facts - and GPs will respect patient choice."

She added: "We also need to remember that whilst clinical guidelines are useful tools for GPs when developing a treatment plan for patients, they are not tramlines.

"GPs are highly trained to prescribe based on the individual circumstances of the patient in front of them - obviously taking age into account, but also any other medication that the patient is using, and all the physical, psychological or social factors that may be impacting their health."

Additional reporting by Press Association

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