The road became Trayvon Martin Avenue during a brief ceremony on Thursday morning near Dr. Michael K. Krop Senior High, where the teen was in 11th grade when he was killed.
The Miami-Dade County Commission approved the new name last month.
“Our students every morning will come out here and see the road that bears Trayvon’s name. His name will continue forever,” said principal Adam Kosnitzky.
Martin, 17, was shot dead while visiting his father in Sanford, in Central Florida, in 2012. The teen was unarmed and walking back from a convenience store when he was shot by George Zimmerman after the two engaged in a struggle.
Zimmerman's acquittal under Florida’s self-defense law in July 2013 sparked the Black Lives Matter movement.