Omicron: How worried should we be about the new Covid variant?

Analysis: Warnings have been loud and clear from the beginning: do not underestimate this virus. Now, after months of relative silence on the genetic front, a new enemy appears to have surfaced

Samuel Lovett
Science Correspondent
Saturday 27 November 2021 00:08
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New Covid variant may pose ‘substantial risk’ to public health, says Sajid Javid

The sudden emergence of a new variant – named omicron by the World Health Organisation (WHO) – has provoked harrowing flashbacks to last winter, when the world was first informed of a new, more transmissible form of the virus.

Now, much like then, there are many questions to which we have few answers: to what extent will the variant diminish the vaccines’ potency? Just how infectious is it? Does it cause greater disease? And what does this all mean for the trajectory of the pandemic?

The scientists are already hard at work exploring these issues and assessing the genetic make-up of the variant – though health officials believe it’s likely to take up to eight weeks until we’re able to develop a clear picture of what’s going on, and what lies ahead.

Even so, to be in this position is an incredible achievement of modern science, given that omicron, or B.1.1.529, exploded onto the scene only a few days ago.

This is one of the many reasons why alarm bells have been rung. In South Africa – once again in the crosshairs after its experience with the beta variant – cases have surged throughout November, with the majority of these infections reported in Gauteng province.

As many as 90 per cent of new cases in the region could have been caused by B.1.1.529, scientists believe, and it’s feared that it is “rapidly taking over” from delta, suggesting it is “fitter” than its viral cousin. If that proves to be the case, it will only be a matter of time before the variant dominates globally.

It’s not only omicron’s swift ascent that has sparked concern, but its genetic profile, too. Scientists are in agreement that B.1.1.529 is “unprecedented” and “very unusual” on account of its wide-ranging mutations, the majority of which are focused in the spike protein – the key with which the virus gains entry to our body’s cells.

It’s been theorised that the variant emerged from an immunocompromised individual who was unable to clear the virus from their system, allowing it to gradually transform over time and acquire one mutation after another before eventually emerging from its evolutionary gym.

These mutations, which read like alphabet soup, have “been associated previously with increased transmission and immune evasion”, says Professor Sharon Peacock, one of the UK experts leading our response to B.1.1.529. “Many mutations are not familiar to us.”

How these mutations change the nature of the variant and interact with one another is yet to be determined. Some believe they will reduce the effectiveness of the vaccines and the protection they confer – the health secretary, Sajid Javid, said on Friday that this was a possibility – while others insist there is a long way to go before the Covid virus can overcome the high walls of our immunological defences.

Regardless of what answers the scientists bring back from their laboratories, it is reassuring to see such a swift response to the variant, which those in Whitehall believe to be the “worst we’ve seen so far”. The UK has jumped straight onto the front foot, placing several countries from southern Africa on its red travel list.

A lesson has been learnt from the government’s inexplicable decision to allow the importation of thousands of cases of the delta variant before restricting travel from India, as a consequence of which a large – unstoppable – wave was seeded in a short period of time.

Even though travel restrictions ultimately won’t stop B.1.1.529 – assuming it does eventually take off on a global level – such measures give us a chance to prepare our response, and to refocus our vaccination and booster efforts, in time for the cold winter months ahead.

Dr Steve Griffin, a virologist at the University of Leeds, summed it up well: “Act now. If it turns out to be a storm in a teacup, then stand down.” There is nothing to be lost from going too hard or fast.

The WHO has advocated the use of the precautionary principle from day one of the pandemic – assume the worst, prepare accordingly – and now is our window of opportunity to act on it.

If B.1.1.529 does fizzle out, as have many variants before it, the world will undoubtedly breathe a collective sigh of relief. Another bullet dodged. But it won’t be long before we find ourselves back in this same dance.

The warnings have been loud and clear from the beginning: do not underestimate this virus. After months of relative silence on the genetic front – leading many to assume that Covid had reached its evolutionary peak – a new enemy has surfaced, one that could well displace delta. How long before another viral contender emerges?

These variants pose the gravest of threats to the global vaccination programme, and – in a world of gross vaccine inequity, sky-high infection rates and partially protected populations – we are actively endorsing the evolution of this virus, to our own detriment.

The WHO recently warned that a degree of complacency had begun to set in. “The fight is over,” many believe; “We won.” This insouciance takes many forms – from not bothering to wear a mask, to governments failing to donate thousands of surplus vaccine doses to those in need – but it can be overcome. Regardless of what comes of B.1.1.529, hopefully it serves as a much-needed reminder that we’re all in this together.

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