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Pfizer and AstraZeneca jabs ‘induce fewer antibodies against Omicron’

Researchers have said there is currently no evidence of increased potential to cause severe disease.

Nina Massey
Monday 13 December 2021 13:15 GMT
Related video: How Vaccinated and Unvaccinated People Can Protect Themselves From the Omicron Variant During the Holidays
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Two doses of the Pfizer and AstraZeneca Covid-19 vaccines induce lower levels of antibodies against Omicron a new study suggests.

Researchers said the findings indicate the new variant has the potential to drive a further wave of infections, including among those already vaccinated.

However, the team from the University of Oxford said there is currently no evidence of increased potential to cause severe disease, hospital admission or deaths in vaccinated populations.

Antibodies are produced by the immune system in response to antigens, in a bid to fight off disease.

(PA Graphics) (PA Graphics)

Prof Matthew Snape, chief investigator on the Com-Cov study, said the data was important but did not look at T cell immunity or non-neutralising antibodies, which are also thought to play a role in preventing illness.

Prof Teresa Lambe, also from the University of Oxford, added: “We have seen across all other variants of concern so far good protection against severe disease and hospitalisation by the regimes that have been used in the UK.”

She said there was a need to be patient while more data is gathered, but said a third booster dose helped make a “stronger memory immune response”.

She added that she was “very hopeful” that vaccines will protect against severe disease and hospital admission in the face of Omicron.

The findings came as Health Secretary Sajid Javid said it would be “completely unfair” to suggest the AstraZeneca jab is not as good as once thought.

Mr Javid was asked on Sky News: “Is it because AstraZeneca wasn’t as good as we initially thought and actually the booster, either Pfizer or Moderna, is what’s helping?”

He replied: “No, I think that would be completely unfair. AstraZeneca has played a phenomenal role in protecting our country.”

He added: “The difference now is… this variant, and different types of vaccines will react in different ways.

“But whether it’s AstraZeneca you had for your first two doses or it’s Pfizer or Moderna, you still need a booster shot to be protected against this new variant.”

Since the start of the booster programme, the Joint Committee on Vaccination and Immunisation (JCVI) has recommended the use of the Pfizer/BioNTech jab, regardless of which vaccine was initially given.

This came after data from the Cov-Boost trial indicated that the Pfizer vaccine is well tolerated as a third dose and provides a strong booster response.

(PA Graphics) (PA Graphics)

Alternatively, the experts advised that a half-dose of the Moderna vaccine could be offered.

Data published by the UK Health Security Agency (UKHSA) on Friday indicated reduced effectiveness of two doses of these vaccines against symptomatic disease due to the Omicron variant compared with Delta.

But it also found the effectiveness was improved by a third dose of vaccine.

UKHSA reported that an mRNA booster jab – which Pfizer and Moderna both are – resulted in an increase in the induction of antibodies irrespective of primary vaccine type.

This was true regardless of which vaccine was used for the variants of concern and variants under investigation.

However, the agency said the duration of restored protection after mRNA boosting is not currently known.

On Sunday, Prime Minister Boris Johnson declared an “Omicron emergency” and announced a new deadline of offering boosters to everyone over 18 by the new year, warning people against thinking the new variant will not make them seriously ill.

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