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Three of Britain’s leading Ebola specialists have said experimental treatments for the deadly Ebola virus must be offered to the people of West Africa, after two US aid workers were administered with the “cure” in Liberia.
The two missionaries, Dr Kent Brantly and Nancy Writebol, are alive and now being cared for at a specialist isolation unit in Atlanta.
Though the pair remain weak – and there is no way of knowing at this stage how much of a help the new drug has actually been – the fact that it was given to the two Americans has resulted in widespread criticism and recriminations in West Africa.
Now Peter Piot, who discovered Ebola in 1976, David Heymann, the director of the Chatham House Centre on Global Health Security and Jeremy Farrar from the Wellcome Trust have said there are in fact several drugs and vaccines under study that could be used to combat the disease.
“African governments should be allowed to make informed decisions about whether or not to use these products - for example to protect and treat healthcare workers who run especially high risks of infection,” they wrote in a joint statement.
The World Health Organization (WHO), “the only body with the necessary international authority” to allow such experimental treatments, “must take on this greater leadership role”, they said.
“These dire circumstances call for a more robust international response,” they added.
Almost 900 people have died from the Ebola virus across Guinea, Liberia and Sierra Leone since the latest outbreak began in February this year. Some strains can have fatality rates of up to 90 per cent, though that of the current crisis appears to be around 60 per cent.
In pictures: Ebola virus Show all 62 1 /62In pictures: Ebola virus In pictures: Ebola virus Ebola virus A health worker from Sierra Leone's Red Cross Society Burial Team 7 carries the corpse of a child in Freetown
In pictures: Ebola virus Ebola virus A health workers from the Sierra Leone's Red Cross Society Burial Team 7 is sprayed with desinfectant after removing a corpse from a house in Freetown
In pictures: Ebola virus Ebola virus Health workers from Sierra Leone's Red Cross Society Burial Team 7 prepare to remove a body from a house in Freetown
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In pictures: Ebola virus Ebola virus Health workers from the Sierra Leone's Red Cross Society Burial Team 7 place a body in a grave at King Tom cemetary in Freetown
In pictures: Ebola virus Ebola virus Mustapha Rogers of the Red Cross talks as health workers from the Sierra Leone's Red Cross Society Burial Team 7 remove a corpse from a house in Freetown
In pictures: Ebola virus Ebola virus A citizen from Mali arrives at a hospital in Murcia city, south-eastern Spain. The protocol for a possible case of Ebola has been activated as the man, who arrived from Mali to Jumilla town in Murcia province five days ago, presents clinical symptoms of high fever and vomiting
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In pictures: Ebola virus Ebola virus Kenyan medical workers show how to handle an infected Ebola patient on a portable negative pressure bed at the Kenyatta national hospital in Nairobi
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In pictures: Ebola virus Ebola virus A health worker sprays disinfectant onto a college in Monrovia, Liberia
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In pictures: Ebola virus Ebola virus A burial team in protective gear bury the body of a woman suspected to have died from Ebola virus in Monrovia, Liberia
In pictures: Ebola virus Ebola virus Healthcare workers in protective gear work at an Ebola treatment center in the west of Freetown, Sierra Leone
AP Photo/Michael Duff
In pictures: Ebola virus Ebola virus A healthcare worker in protective gear is sprayed with disinfectant after working in an Ebola treatment center in the west of Freetown, Sierra Leone
In pictures: Ebola virus Ebola virus A member of the NGO U Fondation leaves a house after visiting quarantined family members suffering from the Ebola virus in Monrovia
In pictures: Ebola virus Ebola virus An Ebola sign placed infront of a home in West Point slum area of Monrovia, Liberia
In pictures: Ebola virus Ebola virus A Liberian man carries his sick brother suspected of having Ebola after being delayed admission to the Island Clinic Ebola Treatment Unit due to a lack of beds at the clinic on the outskirts of Monrovia, Liberia
In pictures: Ebola virus Ebola virus Health workers remove the body a woman who died from the Ebola virus in the Aberdeen district of Freetown, Sierra Leone
In pictures: Ebola virus Ebola virus A health worker fixes another health worker's protective suit in the Aberdeen district of Freetown, Sierra Leone
In pictures: Ebola virus Ebola virus Health workers spray themselves with chlorine disinfectants after removing the body a woman who died of Ebola virus in the Aberdeen district of Freetown, Sierra Leone
In pictures: Ebola virus Ebola virus A woman crawls towards the body of her sister as Ebola burial team members take her sister Mekie Nagbe (28) for cremation in Monrovia, Liberia
In pictures: Ebola virus Ebola virus Sophia Doe sits with her grandchildren Beauty Mandi, 9 months (L) and Arthuneh Qunoh, 9, (R), while watching the arrival an Ebola burial team to take away the body of her daughter Mekie Nagbe, 28, for cremation in Monrovia, Liberia
In pictures: Ebola virus Ebola virus Varney Jonson (46) grieves as an Ebola burial team takes away the body of his wife Nama Fambule for cremation in Monrovia, Liberia
In pictures: Ebola virus Ebola virus Family members grieve as Ebola burial team members prepare to remove the body of Nama Fambule for cremation in Monrovia, Liberia
In pictures: Ebola virus Ebola virus A Liberian burial squad carry the body of an Ebola victim in Marshall, Margini county, Liberia
In pictures: Ebola virus Ebola virus An Ebola burial team dresses in protective clothing before collecting the body of a woman (54) from her home in the New Kru Town suburb of Monrovia, Liberia
In pictures: Ebola virus Ebola virus An Ebola burial team carries the body of a woman (54) through the New Kru Town suburb of Monrovia, Liberia
In pictures: Ebola virus Ebola virus An Ebola burial team dresses in protective clothing before collecting the body of a woman (54) from her home in the New Kru Town suburb of Monrovia, Liberia
In pictures: Ebola virus Ebola virus Health workers in protective gear carry the body of a woman suspected to have died from Ebola virus, from a house in New Kru Town at the outskirt of Monrovia, Liberia
In pictures: Ebola virus Ebola virus Volunteers in protective suit bury the body of a person who died from Ebola in Waterloo, some 30 kilometers southeast of Freetown
FLORIAN PLAUCHEUR/AFP/Getty Images
In pictures: Ebola virus Ebola virus Nowa Paye (9) is taken to an ambulance after showing signs of the Ebola infection in the village of Freeman Reserve, about 30 miles north of Monrovia, Liberia
In pictures: Ebola virus Ebola virus Medical staff members burn clothes belonging to patients suffering from Ebola, at the French medical NGO Medecins Sans Frontieres (MSF) in Monrovia
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In pictures: Ebola virus Ebola virus A medical staff member wearing a protective suit walks past the crematorium where victims of Ebola are burned in Monrovia
In pictures: Ebola virus Ebola virus A Liberian burial team wearing protective clothing loads the body of a 60-year-old Ebola victim after retrieving him from his home
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In pictures: Ebola virus Ebola virus Sick women rest while hoping to enter the new Doctors Without Borders (MSF), Ebola treatment center near Monrovia, Liberia
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In pictures: Ebola virus Ebola virus Hanah Siafa walks in the rain with her children Josephine, 10, and Elija, six, while waiting to enter the new Doctors Without Borders (MSF), Ebola treatment center in Monrovia, Liberia
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In pictures: Ebola virus Ebola virus UNICEF health workers walk through the streets, going house to house to speak about Ebola prevention in New Kru Town, Liberia. The virus has killed more than 1,000 people in four African countries
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In pictures: Ebola virus Ebola virus Local residents watch as public health advocates stage an Ebola awareness and prevention event in Monrovia, Liberia
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In pictures: Ebola virus Ebola virus Public health advocates stage an Ebola awareness and prevention event in Monrovia, Liberia. The Liberian government and international groups are trying to convince residents of the danger and are urging people to wash their hands to help prevent the spread of the epidemic
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In pictures: Ebola virus Ebola virus Hanah Siafa lies with her children Josephine, 10, and Elija, six, while hoping to enter the new Doctors Without Borders (MSF), Ebola treatment center
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In pictures: Ebola virus Ebola virus A health worker examines patients for Ebola inside a screening tent, at the Kenema Government Hospital
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In pictures: Ebola virus Ebola virus A health worker cleans his hands with chlorinated water before entering an Ebola screening tent at the Kenema Government Hospital, about 86 miles from Sierra Leone’s capital Freetown
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In pictures: Ebola virus Ebola virus Aid workers and doctors transfer Miguel Pajares, a Spanish priest who was infected with the Ebola virus while working in Liberia, from a plane to an ambulance as he leaves the Torrejon de Ardoz military airbase, near Madrid, Spain
AP Photo/Spanish Defense Ministry
In pictures: Ebola virus Ebola virus A Liberian money exchanger washes hands between customers as a precaution to prevent infection with the deadly Ebola virus while conducting business in downtown Monrovia, Liberia
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In pictures: Ebola virus Ebola virus A Liberian health worker sprays disinfectant on a drivers boots to stop the spread of the deadly Ebola virus at the Christian charity Samaritan Purse head offices in Monrovia, Liberia. Over 660 people have died of Ebola in West Africa in 2014 making it the world's deadliest outbreak to date according to statistics from the World Health Organisation
EPA
In pictures: Ebola virus Ebola virus A Liberian taxi driver wears protective gloves as a precaution to prevent infection with the deadly Ebola virus whilst driving in downtown Monrovia, Liberia. Many Liberians have taken to wearing gloves and washing hands after every interaction in an attempt to curb the spread of the deadly virus
EPA
In pictures: Ebola virus Ebola virus A Liberian money exchanger wears protective gloves as a precaution to prevent infection with the deadly Ebola virus while transacting business with customers in downtown Monrovia, Liberia
EPA
In pictures: Ebola virus Ebola virus A woman from Liberia takes food to a sick relative in the Ebola isolation unit at the ELWA Hospital where US doctor Kent Bradley is being quarantined having contracted the Ebola virus. Over 660 people have died of Ebola in West Africa in 2014 making it the world's deadliest outbreak to date according to statistics from the World Health Organisation
EPA
In pictures: Ebola virus Ebola virus The disease has now spread to Liberia and, for the first time, Sierra Leone and Nigeria, killing at least 672 people in 1,201 cases, according to the World Health Organisation’s latest figures
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In pictures: Ebola virus Ebola virus Health specialists prepare for work in an isolation ward for patients at the Medecins Sans Frontieres facility in southern Guinea
AFP/Getty Images
In pictures: Ebola virus Ebola virus A Liberian street vendor wears protective gloves as a precaution to prevent infection with the deadly Ebola virus while transacting business with customers in downtown Monrovia, Liberia
EPA
In pictures: Ebola virus Ebola virus A nurse from Liberia sprays preventives to disinfect the waiting area for visitors at the ELWA Hospital where a US doctor Kent Bradley is being quarantined in the hospitals isolation unit having contracted the Ebola virus, Monrovia, Liberia
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In pictures: Ebola virus Ebola virus Staff of the 'Doctors without Borders' ('Medecin sans frontieres') medical aid organisation carry the body of a person killed by the virus
In pictures: Ebola virus Ebola virus A Liberia man (right) talks to a nurse (left) about the health of his relative who is in the isolation unit of the ELWA Hospital where a US doctor Kent Bradley is being quarantined having contracted the Ebola virus, Monrovia, Liberia
EPA
In pictures: Ebola virus Ebola virus A nurse from Liberia walks to spray preventives to disinfect the waiting area for visitors at the ELWA Hospital where a US doctor Kent Bradley is being quarantined in the hospitals isolation unit having contracted the Ebola virus
EPA
In pictures: Ebola virus Ebola virus Staff of the Christian charity Samaritan's Purse put on protective gear in the ELWA hospital in the Liberian capital Monrovia
AFP
In pictures: Ebola virus Ebola virus Lagos State Health Commissioner Jide Idris, speaks, during a news conference in Lagos, Nigeria. No one knows for sure just how many people Patrick Sawyer came into contact with the day he boarded a flight in Liberia, had a stopover in Ghana, changed planes in Togo, and then arrived in Nigeria, where authorities say he died days later from Ebola
AP Photo/Sunday Alamba
In pictures: Ebola virus Ebola virus Staff of the Christian charity Samaritan's Purse put on protective gear in the ELWA hospital in the Liberian capital Monrovia. An American doctor battling West Africa's Ebola epidemic has himself fallen sick with the disease in Liberia, Samaritan's Purse said
AP
In pictures: Ebola virus Ebola virus Protective gear including boots, gloves, masks and suits, drying after being used in a treatment room in the ELWA hospital in the Liberian capital Monrovia
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In pictures: Ebola virus Ebola virus A Liberian man holding a Civet being sold on a roadside as bush meat in Lofa County. Bush meat is one of the major carriers of the Ebola virus. The Liberian government and International partners have warned people to not eat it. The World Health Organisation (WHO) reported that a total of 888 Ebola cases including 539 deaths have been recorded in West Africa since February
AFP
In pictures: Ebola virus Ebola virus People unload protection and healthcare material at Conakry's airport, to help fight the spread of the Ebola virus and treat people who have been already infected
AFP/Getty Images
In pictures: Ebola virus Ebola virus Body of evidence: health workers transport a casket of a nun whose death resulted from an Ebola infection in Zaire in 1995
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In pictures: Ebola virus Ebola virus Peter Piot in Yambuku, northern Congo (then Zaire), in 1976, where he was part of the original team to discover the Ebola virus
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In pictures: Ebola virus Ebola virus A member of Doctors Without Borders helps to unload protection and healthcare materials in Guinea
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In pictures: Ebola virus Ebola virus Doctors in protective gear work inside the Medecins Sans Frontieres isolation ward as Guinea faced the worst ever outbreak of the Ebola virus
Getty Images
Liberia’s assistant health minister, Tolbert Nyenswah, said that the news of Dr Brantly and Ms Writebol’s treatment had “made our job very difficult” as dying patients and their relatives in Africa request the same “cure”.
Dr Nyenswah told the Wall Street Journal : “The population here is asking: 'You said there was no cure for Ebola, but the Americans are curing it?'”
The US aid workers were given ZMapp, a drug made from antibodies produced in a lab that has never gone through human trials or been approved by the US’s FDA Food and Drug Administration.
Piot, Farrar and Heymann questioned why Africans were not being given the same chance. If the deadly virus was raging though wealthy countries, they said, medical agencies “would begin discussions with companies and labs developing these products and then make rapid decisions about which of them might be appropriate for compassionate use”.
“Experimental treatments shouldn't be rolled out generally without prior safety testing,” they said in their statement, issued in London late on Tuesday.
“But in the face of the critical challenge in West Africa, the WHO and Western medical agencies should be helping countries weigh the risks and benefits of limited deployment of the best (drug and vaccine) candidates to those in the greatest need, while continuously monitoring safety and efficacy.”
An electron micrograph of the Ebola virus Their call for action from the World Health Organisation adds weight to the growing impetus demanding the outbreak in West Africa be brought under control, and which the UK Faculty for Public Health’s Dr John Ashton wrote about in this week’s Independent on Sunday.
On Monday the World Bank pledged up to $200 million (£120 million) in emergency funding to help Liberia, Sierra Leone and Guinea.
And though cost has been cited as one of the major restrictive factors preventing drug companies from rolling out Ebola treatments across Africa, the WHO said it “would not recommend any drug that has not gone through the normal process of licensing and clinical trials”.
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