The Vice President launched a scathing attack on UN agencies at an annual dinner held by a Christian human rights organisation, saying they "often failed to help the most vulnerable communities especially religious minorities".
"We will no longer rely on the United Nations alone to assist persecuted Christians and minorities in the wake of genocide and the atrocities of terrorist groups," Mr Pence told the event, which was organised by the Washington-based non-profit organisation In Defense of Christians.
"The United States will work hand in hand from this day forward with faith-based groups and private [organisations] to help those who are persecuted for their faith. This is the moment, now is the time, and America will support these people in their hour of need," he said.
He did not specify what UN programmes would be cut.
A number of faith-based groups had had their funding requests denied, despite having "proven track records and deep roots in these communities", he said.
He added: "Those days are over. Our fellow Christians and all who are persecuted in the Middle East should not have to rely on multinational institutions when America can help them directly."
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