Thomas Tuchel’s side blew away Tottenham with a second half blitz to win 3-0 on Sunday afternoon.
These two sides have already met this season, with Villa troubling the Premier League title contenders significantly more than their three-goal losing margin suggests.
Both sides are expected to make a number of changes for the midweek game.
Here’s all the information you need before the fixture.
When is it?
The match will kick off at 7:45pm BST on Wednesday 22 September at Stamford Bridge.
How can I watch?
The game will not be shown live on television in the United Kingdom, though highlights can be seen on Quest from 10.30pm BST on Wednesday 22 September.
Chelsea — Kepa; James, Chalobah, Sarr, Chilwell; Saul, Kante; Loftus-Cheek, Ziyech, Hudson-Odoi; Werner.
Aston Villa — Steer; Cash, Tuanzebe, Hause, Young; Nakamba, Sanson; Traore, Buendia, El Ghazi; Archer.
Aston Villa: 13/2
With both sides likely to look at the breadth and depth of their squad, this could be a tighter game than some might suggest. Aston Villa have enviable depth for a club of their stature after a strong summer of business, but Chelsea should be too strong. Chelsea 2-1
Join our new commenting forum
Join thought-provoking conversations, follow other Independent readers and see their replies