Nemanja Vidic has been ruled out of Manchester United's Champions League trip to Wolfsburg, leaving Sir Alex Ferguson with a threadbare defence as his team attempt to secure top spot in Group B.
United had hoped Vidic would have recovered from the flu bug that kept him out of Saturday's win at West Ham.
However, the Serbian was absent as the Red Devils checked in for the short flight to Germany, giving their manager a major headache.
His list of injured defenders includes skipper Gary Neville and England international Wes Brown, who both limped off at Upton Park, plus longer-term casualties Rio Ferdinand, John O'Shea and Jonny Evans. With the Da Silva brothers, Fabio and Rafael, also sidelined, the only orthodox defender Ferguson has in his squad is left-back Patrice Evra.
Ferguson has already revealed his intention to play Michael Carrick in central defence, while Darren Fletcher seems certain to occupy a defensive berth, too, although which one is open to debate.
Among the less familiar faces in the United party are Oliver Gill, son of chief executive David, Magnus Eikrem, Cameron Stewart, Matt James and Oliver Norwood.
Normally, Ferguson would only class outings such as this as useful staging posts in a young player's development.
However, on this occasion, there is the very real possibility they could play a prominent part.
In addition to the defensive problems - first-choice keeper Edwin Van der Sar is also missing - Ferguson has taken the option of leaving Wayne Rooney and Dimitar Berbatov at home, meaning Michael Owen and Danny Welbeck are the only strikers in his 19-man squad.
Given Wolfsburg are unbeaten at home in this season's competition, it would appear United's best hope of finishing top would be for CSKA Moscow to beat Besiktas in Istanbul, which would leave the Red Devils at the head of affairs no matter what their result.
At least it should mean Paul Scholes should retain his place for a game the former England star feels will round off what has been a harder group than seemed likely when the draw was made.
"This was one of the toughest groups," he said. "We had to go to Moscow, which is always difficult, especially on a plastic pitch, and it is the same in Turkey, yet we managed to win both games.
"CSKA and Besiktas went on to prove at Old Trafford that they are very capable teams and, when you take into account Wolfsburg are the German champions, we did well to qualify as early as we did."
He continued: "We want to win the game and finish top of the group. How much difference that makes to who we get in the next round, I am not too sure. There are lots of good teams at that stage of the tournament."
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