In their last fixture, City sealed the Carabao Cup title after beating Aston Villa 2-1 at Wembley Stadium.
Meanwhile, Wednesday suffered a 3-1 defeat at home to Derby.
The Championship side face a tough task when City visit with another trophy in their sights. Are they capable of an upset?
Here’s all you need to know.
When is the match?
The match takes place on 4 March. Kick-off is at 7.45pm.
How can I watch it?
The match will be aired on BBC One, with coverage starting from 7:30pm. It will be free to watch for viewers with a valid TV licence.
The game can also be streamed for free via BBC iPlayer.
What’s the team news?
The hosts have made four changes to the side that lost to Derby on Saturday, with Joe Wildsmith, Dominic Iorfa, Joey Pelupessy and Alessio Da Cruz all coming into the starting XI.
Meanwhile, City make six changes from their Carabao Cup-winning XI, with Gabriel Jesus, Bernardo Silva, Benjamin Mendy, Joao Cancelo, Nicolas Otamendi and Riyad Mahrez all returning.
Wednesday: Wildsmith; Palmer, Fox, Lee, Pelupessy; Bannan, Borner, Murphy, Iorfa; Da Cruz, Forestieri
City: Bravo; Cancelo, Stones, Otamendi, Mendy; Rodri, David Silva, Bernardo Silva, Mahrez; Jesus, Aguero
City have momentum and the taste for silverware this season now. An upset should never be ruled out in the cup, but a strong City line-up should blow away Wednesday tonight.
Wednesday 0-6 City
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