Having just missed out on Champions League action once again with a fifth-place finish in the Premier League last term, the Foxes are in Group C of Europe’s second competition, along with Spartak Moscow and Legia Warsaw.
Brendan Rodgers will be hoping to guide his side through the group stage into the last 32 - and there finally pick up a long-overdue first victory in a European knock-out tie of his entire managerial career.
Napoli make for a tough first opponent, though, with the Italian side having just beaten Juventus domestically at the weekend and remaining with a 100 per cent league record so far.
Here’s everything you need to know ahead of the match.
When is the game?
The match kicks off at 8pm on Thursday 16 September at the King Power Stadium.
Where can I watch it?
All Europa League and Champions League games are on BT Sport again this season. The match will be shown live on BT Sport 2 and BT Sport Ultimate, while subscribers can stream it via the BT Sport app or desktop website.
What is the team news?
Long-term injury absentees Wes Fofana and James Justin are still nowhere close to a return for Leicester, while Nampalys Mendy is also out. Ayoze Perez can play as his suspension is domestic only. Brendan Rodgers might give Patson Daka a full debut and Jonny Evans is expected to start too - the key centre-back is yet to do so this term.
Napoli are without a host of squad players including Diego Demme, Faouzi Ghoulam and goalkeeper Alex Meret. Forward Dries Mertens is also out and the inspirational Lorenzo Insigne is another big doubt. There could be issues at left-back too if Mario Rui doesn’t recover.
LEI - Schmeichel; Pereira, Evans, Soyuncu, Bertrand; Perez, Soumare, Tielemans, Lookman; Iheanacho, Daka
NAP - Ospina; Di Lorenzo, Koulibaly, Manolas, Malcuit; Ruiz, Anguissa, Zielinski; Politano, Osimhen, Lozano
The Foxes will have to work hard and keep the line-up as close to full-strength as possible to get a decent result at the start of the group campaign. Leicester 1-1 Napoli.
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