Barcelona have endured a tough start to their La Liga campaign and were held in their opener at Dortmund, leaving all four sides with one point after a game.
Inter Milan meanwhile drew with Slavia Prague, meaning that it’s all to play for. Follow the latest updates from Spain here.
When is it?
Kick-off at the Camp Nou is at 8pm (BST) on Wednesday 2 October.
How can I watch it?
The match will be broadcast live on BT Sport ESPN and can be streamed live online via the BT app and website.
Lionel Messi is expected to miss out with an adductor problem, however, the Argentinian may be able to make the bench. Ousmane Dembele is also returning from injury and has only recently returned to training meaning he is unlikely to feature.
Inter boast an injury-free squad with Alexis Sanchez expected to make the starting line-up after scoring twice before being sent off against Sampdoria last week.
Good afternoon and welcome to our live coverage of this today's Champions League fixtures.
Liverpool vs RB Salzburg
This match may not be as straightforward for Liverpool as they may have hoped it could be.
Losing the first game of the group, 2-0 vs Napoli, has put Liverpool in a situation where they could ill-afford a second defeat.
Alisson remains short of fitness and is joined tonight on the sideline by Joel Matip, opening the door for Joe Gomez to partner Virgil Van Dijk at the back.
"The way Salzburg plays is made to surprise bigger teams. But if there's anybody in the world who knows more about the way they play, how they do what they do, then it's probably me.
"I've followed that way for a long, long time. I had a similar idea when I started as a manager, so I know where the difficulties are."
Lille vs Chelsea
In a tricky group, Chelsea could really do without losing this evening. Defeat against Valencia at home means they are already playing catch-up, despite Frank Lampard's insistence that the latter games of the group are more important.
Cesar Azpilicueta: "Lille may have less experience than us but they are at home.
"They have great supporters, the team will obviously rely on the supporters to put a lot of pressure on us. There will be a lot of pressure. This is a special competition.
"Lille have been fighting hard to get into this competition. They have a lot of talent. They move well, pass and create opportunities. Also they have experienced players like Loic Remy, who I have played with before.
"But regardless we are here to take three points home."
Barcelona vs Inter Milan
Elsewhere in Europe, there is a titanic clash taking place at the Nou Camp this evening: Barcelona vs Inter Milan.
The Catalan giants drew at Borussia Dortmund in their first match and can take control of the group with a win tonight.
This fixture produced one of the most memorable Champions League ties in the competition's history when Jose Mourinho's Inter Milan side executed a brilliant plan over two legs en route to winning the final in 2010.
Miguel Delaney looks back at the compelling clash...
Liverpool vs RB Salzburg team news
As expected, Joe Gomez replaces the injured Joel Matip in defence as the only change to Liverpool's strongest team.
Liverpool: Adrian, Alexander-Arnold, Gomez, Van Dijk, Robertson, Fabinho, Wijnaldum, Henderson, Mane, Salah, Firmino.
Subs: Kelleher, Lovren, Milner, Keita, Oxlade-Chamberlain, Lallana, Origi.
RB Salzburg: Stankovic, Kristensen, Onguene, Wober, Ulmer, Mepu, Junuzovic, Minamino, Szoboszlai, Daka, Hwang
Subs: Coronel, Ashimeru, Koita, Ramalho, Farkas, Haaland, Okugawa
There are two early matches taking place in the competition tonight and just the one goal after 45 minutes.
Genk 0-0 Napoli
Slavia Prague 0-1 Borussia Dortmund (Achraf Hakimi)
Barcelona vs Inter Milan Team news
Lionel Messi is fit to start just his second game of the season after an injury-hit start to the campaign.
Romelu Lukaku is not fit and there is a Nou Camp return for Alexis Sanchez.
Barcelona XI: Ter Stegen, N. Semedo, Piqué, Lenglet, S. Roberto, Sergio Busquets, Arthur, F. De Jong, Suárez, Messi, Griezmann
Subs: Neto , Rakitic, Todibo, Dembele, Wague, Vidal, Carles Perez
Inter Milan XI: Handanovic, Godin, De Vrij, Skriniar, Candreva, Sensi, Barella, Brozovic, Asamoah, Lautaro Martinez, Alexis Sanchez
Subs: Padelli, Gagliardini, Vecino, Politano, Esposito, D'Ambrosio, Biraghi
Lille vs Chelsea team news
Kante starts for Chelsea as Willian makes his 300th appearance for the club. Loic Remy is on the bench for the hosts.
Lille XI: Maignan; Çelik, Gabriel, José Fonte, Reinildo; Soumaré, André; Araujo, Ikoné, Bamba; Osimhen
Subs: Leo Cesar, Soumaoro, Xeka, Remy, Yusuf Yazıcı, Sanches, Bradaric
Chelsea XI: Kepa; Azpilicueta, Tomori, Zouma; James, Kante, Jorginho, Alonso; Willian, Abraham, Mount.
Subs: Caballero, Christensen, Pedro, Kovacic, Giroud, Hudson-Odoi, Batshuayi
What next for Christian Pulisic?
The European Champions are in the house
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