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Manchester United manager Louis van Gaal has confirmed that defenders Phil Jones, Jonny Evans and Chris Smalling will all be sidelined for the fixture with West Ham on Saturday.
Fellow defender Tyler Blackett will also miss out because of suspension.
"We have nine injuries and one suspension with Blackett," Van Gaal said today. "The younger players can have their chance now.
"Evans' bone is bruised. Smalling left yesterday's session because he had stiff legs. I won't take risks with players."
Speaking about the 5-3 thrashing by Leicester City last weekend, Van Gaal has accepted that his players are not "robots" and are capable of making mistakes.
Show all 22 1 /22Leicester City 5 Manchester United 3 player ratings Leicester City 5 Manchester United 3 player ratings Leicester: Kasper Schmeichel Couldn’t be faulted for the goals, and didn’t have too many saves to make. 5
Leicester City 5 Manchester United 3 player ratings Ritchie De Laet Never stopped working up and down the right flank and set up Jamie Vardy’s goal with a superb through ball after dispossessing Juan Mata. 7
Leicester City 5 Manchester United 3 player ratings Liam Moore Grew into the game after an uncertain start and was a threat at set-pieces. 6
Leicester City 5 Manchester United 3 player ratings Wes Morgan 6 A commanding performance from the centre back that helped to keep Robin van Persie quiet for the most part.
Leicester City 5 Manchester United 3 player ratings Paul Konchesky Typically industrious display, with plenty of bursts forward and crunching tackles.
Leicester City 5 Manchester United 3 player ratings Esteban Cambiasso Thundered in the equaliser to make it 3-3, and kept things ticking over in midfield with his accurate passing.
Leicester City 5 Manchester United 3 player ratings Danny Drinkwater Former Manchester United player showed some fantastic vision. 7
Leicester City 5 Manchester United 3 player ratings Dean Hammond Steady in the middle for the Foxes. 6
Leicester City 5 Manchester United 3 player ratings David Nugent Great link-up play with Vardy and Ulloa, and made no mistake from the spot. 8
Leicester City 5 Manchester United 3 player ratings Jamie Vardy Constant source of anguish for the United defence. 9
Leicester City 5 Manchester United 3 player ratings Leonardo Ulloa £8m striker is already up to five goals this season after his impressive double. 8
Leicester City 5 Manchester United 3 player ratings Manchester United: David De Gea Couldn’t have done much for any of the goals, and offered no protection by his threadbare defence. 5
Leicester City 5 Manchester United 3 player ratings Marcos Rojo Struggled against Vardy all afternoon and couldn’t get forward as much as he would have liked. Good pass into Falcao in the build-up to United’s first goal. 5
Leicester City 5 Manchester United 3 player ratings Tyler Blackett Gave the ball away in dangerous areas, and sent off when he conceded a penalty for bringing down Vardy. A nightmare afternoon for the youngster.
Leicester City 5 Manchester United 3 player ratings Jonny Evans Looked reasonably assured before going off injured after half an hour. 5
Leicester City 5 Manchester United 3 player ratings Rafael Lost his head when he unnecessarily fouled Jamie Vardy for the penalty that got Leicester back in the game. Often caught out of position. 5
Leicester City 5 Manchester United 3 player ratings Ander Herrera Took his goal beautifully, but on the back foot for much of the afternoon. 5
Leicester City 5 Manchester United 3 player ratings Wayne Rooney Beautifully weighted pass for Di Maria’s goal, but peripheral for much of the game. Booked for dissent after the Blackett sending off. 5
Leicester City 5 Manchester United 3 player ratings Angel Di Maria Scored stunning goal, and always a threat with his pace and direct running. Taken off for the final quarter of an hour. 6
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Leicester City 5 Manchester United 3 player ratings Daley Blind Very comfortable in possession but ultimately couldn’t match the Leicester midfield's intensity. 5
Leicester City 5 Manchester United 3 player ratings Robin van Persie Scored deflected goal early on, but did little else thereafter. 5
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Leicester City 5 Manchester United 3 player ratings Radamel Falcao Did superbly to create Robin van Persie’s goal, and so unlucky not to score with volley that hit the bar. Taken off for the final 20 minutes. 6
He added: "I don't think my players are robots. They are humans and make errors. It's about overcoming things."
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