Kane twice went down in the first half clutching an ankle and although he hobbled on, he did not come back out for the second half.
“Two ankles, the first was a bad tackle, it was Thiago, the second one I didn’t know well,” said his manager Jose Mourinho after the game. “But two injuries in both ankles, the second one worst than the first one – a few weeks, I don’t know. There are some players you can’t replace. When it happens it happens but I believe we have to fight against it, we cannot do anything else.”
Kane’s injury capped a disappointing night for Spurs, who never fully recovered after Son Heung-min’s early strike was ruled by VAR for a marginal offside.
Mourinho felt his side made too many errors.
“It is very hard to resist, to (overcome), so many individual defensive mistakes,” he said. "It's impossible, unless you score four goals against Liverpool, which is not easy. But every time we reacted the next mistake was coming. It is very difficult to fight against so many mistakes.
"Some of the guys are very disappointed because some of them had a very good performance, but we were punished by individual mistakes."
Spurs now face a busy schedule with two games a week across the Premier League, FA Cup and Europa League. Kane has scored 14 goals and provided 13 assists this season for Tottenham, which is sixth in the league.
Join our new commenting forum
Join thought-provoking conversations, follow other Independent readers and see their replies