Spurs are currently third in their group, so as well as seeing Antonio Conte’s early approach in terms of tactics, his team selection might also give a hint as to whether he’s keen to focus on the potential for European glory this season - they need to win against the Dutch side who beat them two weeks ago.
Conte is expected to be in the dugout for the match, despite not having officially taken a training session yet as he awaits a work visa after being appointed boss to replace Nuno Espirito Santo.
Harry Kane has already scored three times in this competition this term - but he’s one of several players whose individual performances have come in for criticism this term.
Here’s everything you need to know ahead of the game.
When is the match?
The game kicks off at 8pm on Thursday 4 November at the Tottenham Hotspur Stadium.
Where can I watch it?
The match will be broadcast live on BT Sport ESPN. Subscribers can stream the match via the BT Sport app and desktop website.
TOT - Lloris; Royal, Dier, Romero, Davies, Reguilon; Skipp, Hojbjerg; Lucas, Son, Kane
VIT - Schubert, Doekhi, Dasa, Rasmussen, Bazoer, Tronstad, Bero, Frederiksen, Gboho, Wittek, Buitink.
Antonio Conte’s first game and a team who were dismal last time out? It can only be a confidence-boosting home win to inspire hope in the fanbase. Spurs 2-0 Vitesse.
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