Monaco midfielder Youssouf Fofana and Ibrahima Konate of Liverpool come in in their places.
Kylian Mbappe, Olivier Giroud and Ousmane Dembele start together in an attacking three with Antoine Griezmann once again set to reprise the midfield role that he has proven so adept in at the tournament so far.
Morocco have also made changes to the side that so famously beat Portugal last time out.
West Ham centre-back Nayef Aguerd and Noussair Mazraoui of Bayern Munich have both been included with coach Walid Regragui reverting to a back-five against the defending champions.
France vs Morocco confirmed teams
France: Lloris; Kounde, Varane, Konate, Theo Hernandez; Tchouameni, Fofana; Dembele, Griezmann, Mbappe; Giroud
Morocco: Bono; Hakimi, El Yamiq, Aguerd, Saiss, Mazraoui; Amrabat, Ounahi; Ziyech, En Nesyri, Boufal
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