Rose now has the most wins on the PGA Tour for an Englishman and had led from the second day before heading into the final round three shots ahead of Adam Scott.
Although the Australian closed with four successive birdies Rose, who picked up two shots of his own in that stretch, had built up enough of an advantage to still win by two with a 21-under-par total.
It was not all plain sailing, however, as Rose bogeyed three of his first five holes, before a run of three birdies in four holes from the seventh restored some order.
He was helped by the fact Scott failed to take advantage after playing his opening 14 holes in level par, including one bogey and a birdie, meaning his race to the finish came too late to have any effect.
Rose, in only his second tournament after changing club manufacturer, closed with a 69 to secure his third win and 16th top-10 finish in his last 24 worldwide events, and admitted his delight at landing 10 wins on the PGA Tour.
“Double-digit in wins sounds really cool and winning is never easy,” Rose said.
“When you’ve beaten a high-class field at a great venue, that satisfies you as a player and, mentally, it counts as a win-and-a-half.
“Over the first six holes today, it was a case of anything that could go wrong did go wrong, and I felt I didn’t play that badly. In the past I might have got a little rattled, a little shaken by that start but I didn’t today.
“I had a bit of a gut-check time on the seventh hole but I’d been playing so well all week. I just went about my business and it really started to turn around.
“Twenty-one under par around Torrey Pines is great golf, but you had to do it and it felt like I had to work hard for this. I haven’t won in January since about 2002, so this feels great.”
His Ryder Cup team-mate Rory McIlroy was also three under par for his final round, leaving him in a share for fifth on 14 under.
Tiger Woods saved his best round of the week until last with a 67, which included six birdies, lifting him to 10 under and joint 20th.
Next up for Rose will be the Saudi International, with Brooks Koepka, Dustin Johnson and fellow victor last week Bryon DeChambeau also in the field.
Join our new commenting forum
Join thought-provoking conversations, follow other Independent readers and see their replies