Verstappen finished a close second with teammate Daniel Ricciardo completing the podium, but it was all about Hamilton who can now clinch the drivers' crown claim in the United States in a fortnight's time.
The 2017 Formula 1 grid
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In a season where he surpassed Michael Schumacher's pole position record Hamilton can move to four world titles making him the most decorated Brit in F1 history and leaving only Schumacher (seven world titles) and Juan Manuel Fangio (five) ahead of him.
Contrastingly, just six weeks ago Vettel was clear at the top - now the German requires something special to happen if he is deny Hamilton, and the man himself can scarcely believe how things have turned in his favour with just four races remaining.
"I think it is unbelievable really to think that we are where we are," he said. "I could only have dreamed of having this kind of gap. All I can really say is that I have to put it down to my team. They've done a phenomenal job, reliability has really been on point.
"There is still a long way to go, 100 points is a lot of points and anything can happen. I just need to keep my head down."
Hamilton secured his last title in Austin two years ago and has won the last three races at the Circuit of the Americas. He does not need to win another race between now and the season's end to sew up the title but he is not about to let up.
"To be honest there is not really any need to change my approach," he said. "I just don't think there is a need to make any changes. I'm not taking crazy risks to be in the position I'm in.
"We will continue to try and keep doing what we are doing, there isn't much more I can do, sometimes when you come off the gas a little you cause yourself more trouble than you need."
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