Multiple cars were crossing over the bridge at the time, including one the size of a tractor-trailer.
Desperate rescue efforts are currently under way to find survivors in the freezing waters, with just two people pulled from the river so far and at least seven unaccounted for.
Photos show the Singapore-flagged Dali cargo ship rammed into the bridge, with parts of the mangled metal lying on top on top of the coloured containers.
Much of the bridge is submerged beneath the Patapsco River while concrete slabs lie across the ship.
See the dramatic images below:
Dramatic new aerial photos have revealed the true extent of the damage (BBC News)
At least seven people are missing after the crash (Sky News)
Desperate rescue efforts are currently under way to find survivors in the freezing waters (Bloomberg Television)
Part of the mangled metal sits on top of the boat (AP)
Parts of the Francis Scott Key Bridge remain after a container ship (AP)
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