Chelsea needed penalties to advance in the Carabao Cup for a second consecutive round as they edged past Southampton with a 4-3 shoot-out victory at Stamford Bridge following a 1-1 draw.
Reece James again provided the decisive kick, just as he did against Aston Villa in the previous round, with Theo Walcott and Will Smallbone missing for the Saints.
Kai Havertz headed Chelsea into the lead seconds before half-time, guiding a header into the bottom corner from a corner.
But Southampton would force spot-kicks when Che Adams fired in on the rebound after Kyle Walker-Peters’ effort was saved by the legs of Kepa Arrizabalaga.
Across London, Calum Chambers scored his first goal in more than two years before Eddie Nketiah punished his former club to send Arsenal into the quarter-finals with a 2-0 win over Leeds.
Chambers scored with his first touch of the night after coming off the bench to replace the injured Benjamin White 10 minutes into the second half.
And former Leeds loanee made sure of the Gunners’ place in the quarter-finals when he punished a mistake from Liam Cooper, whose defensive header never had the power to reach Illan Meslier.
Instead Nketiah skipped through, lifting the ball over the goalkeeper before watching his scuffed finish tuck just inside the post as Leeds defenders scrambled to get back.
The result means Arsenal have now won six of their last eight in all competitions, and are unbeaten since August.
It also went to penalties at the Kiyan Prince Foundation Stadium, where League One Sunderland dumped out QPR with a 3-1 shoot-out victory after a goalless draw.
Charlie Austin thought he had scored a late winner to send QPR into the last eight for the first time since 1988.
But a tight offside call went against the home side, and Austin’s misery continued when his spot-kick - the first of the shoot-out - was saved by Sunderland goalkeeper Lee Burge.
He was not the only culprit, though, with Ilias Chair and Yoann Barbet failing to find the target from the spot as QPR went out to League One opposition for a fourth year in a row.
Chelsea need penalties once more as they edge past Southampton in Carabao Cup
Chelsea needed another shootout to earn a place in the Carabao Cup quarter-finals with Southampton beaten 4-3 on penalties after a 1-1 draw in the 90 minutes at Stamford Bridge.
Reece James again provided the decisive kick like he had done in the previous round against Aston Villa after Theo Walcott and Will Smallbone had failed from 12 yards for the Saints.
The Blues had needed a shootout to get past Aston Villa in the previous round.
Reaction from Ralph Hasenhuttl
Chelsea through to Carabao Cup quarter-finals
Southampton put in an impressive performance at Stamford Bridge but it was the home side who were victorious on the night. Chelsea join Arsenal, 2-0 winners over Leeds, and Sunderland, 3-1 penalty shoutout winners over QPR, in the next round.
Chelsea beat Southampton on penalties
A well-fought affair at Stamford Bridge came down to spot kicks after Chelsea and Southampton couldn’t be separated after 90 minutes.
Kai Havertz scored for the Blues just before half-time but his team were pegged back immediately after the restart by Che Adams turning home richocheted shot from Kyle Walker-Peters.
Both teams went after a winner with play alternating from end-to-end but no-one could find a winner.
The result had to be decided by penalties, Theo Walcott and Mason Mount both had their penalties saved before Will Smallbone blasted his effort over the crossbar. Reece James had the final penalty and a chance to win it for Chelsea and he slotted it home.
Chelsea are through to the quarter-finals.
Penalties: Chelsea 4 - 3 Southampton
He scores! Chelsea win! The beat Southampton 4-3 on penalties. Reece James witht he decisive penalty, slotting it coolly to Fraser Forster’s left and the goalkeeper dove the opposite way.
Penalties: Chelsea 3 - 3 Southampton
He does! Romeu scores for Southampton. Reece James has a kick to win it for the Blues.
Penalties: Chelsea 3 - 2 Southampton
Chelsea take the lead! Ben Chilwell finding the inside side netting! Oriol Romeu has to score.
Penalties: Chelsea 2 - 2 Southampton
Miss! Wil Smallbone blasts his effort high over the crossbar! It’s a horrible miss.
Penalties: Chelsea 2 - 2 Southampton
Callum Hudson-Odoi draws Chelsea back level!
Penalties: Chelsea 1 - 2 Southampton
Shane Long scores for Southampton! Pressure back on Chelsea.
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