Mauricio Pochettino will need to rely on the depth of his squad as Tottenham welcome Southampton to White Hart Lane.
Harry Kane is just one of five players out for Tottenham as they try to maintain their grip on a Champions League place. Kane injured his ankle in the 6-0 win against Millwall in FA Cup and is joined on the sidelines by Kyle Walker (ankle), Victor Wanyama (neck), Danny Rose (knee) and Erik Lamela (hip).
Pochettino does however welcome back the influential Moussa Dembele after his ankle injury and he will hope he has enough in his side to keep up the good record he has against his former employers. He has won three, drawn one and lost just one against Southampton.
However, Claude Puel has no such injuries worries and even has Martin Caceres match-fit after his signature on a free. After such an eventful win at Watford last time out, expect this Super Sunday match-up to be a more tightly contested affair.
Follow the action with our liveblog below...
What time does it start?
Tottenham Hotspur vs Southampton kicks off at 2.15pm on Sunday 19 March.
Where can I watch it?
The match will be shown live on SkySports One from 1.00pm. Highlights will be shown from 10.30pm on BBC One.
It’s a big game for…
Vincent Janssen. The Dutch forward has struggled since joining in the summer. He has only scored one with one assist in 19 appearances for Spurs. With Kane out injured and scoring his first goal in open play against Millwall in the FA Cup, it’s time for this striker to pay back the faith Pochettino has put in him.
14. For the first time since 1964/65, Tottenham are unbeaten in their first 14 home matches in the top-flight.
2000 brought a Premier League classic with Southampton on the wrong end of a seven-goal rout at White Hart Lane.
Player to watch…
Manolo Gabbiadini. Since joining from Napoli to Southampton for £14.45 million, Gabbiadini has taken English football by storm. The Italian could become the third player in Premier League history to score in each of his first four appearances, after join Mick Quinn and Diego Costa.
Southampton 1 (Van Dijk) Tottenham 4 (Alli 2, Kane, Son), Premier League, December 2016
Tottenham 1 (Son) Southampton 2 (Davis 2), Premier League, May 2016
Southampton 0 Tottenham 2 (Kane, Alli), Premier League, December 2015
Tottenham to win: 17/25
Southampton to win: 17/4
(Odds provided by 888 Sports)
Good afternoon and welcome to The Independent's live coverage of Southampton's trip to White Hart Lane. Spurs welcome their opponents without their main man, Harry Kane, which will fill Claude Puel's men with confidence. During his absence last time, they only managed win two out of five league games, so today will certainly be interesting.
Team news and minute-by-minute coverage of the action coming shortly.
'If it is not broken, then don't fix it'...
Southampton only have one clean sheet in their previous 25 visits to Tottenham, but without Kane, will this be the case today?
The players begin to march out onto the pitch.
Kick off qt 14:15.
Southampton kick off to get the first half underway. Game on!
Eriksen delivers a delicate ball through to Son to open up the Southampton defence. The Tottenham lad manages to get a strike on goal, but he is denied by Forster.
The visitors have started quickly and they are controlling possession at the moment.
Tadic has gone to ground holding his head, so the referee has pulled play back.
Tadic dinks a ball over the top to Gabbiadini, who bursts through on goal towards Lloris. To the relief of the home fans, the offside flag was raised.
Yellow card: Dier flies into a challenge with his studs raised. He does not get the ball and Redmond falls to the ground clutching his ankle.
Join our new commenting forum
Join thought-provoking conversations, follow other Independent readers and see their replies