The pair will both undergo late fitness tests following hip injuries.
The Belgian defender missed Wednesday's defeat at Chelsea due to the issue, while Winks sustained a similar injury during the loss at Stamford Bridge.
Mauricio Pochettino remains without Dele Alli (hamstring) and Eric Dier (tonsillitis).
Though Harry Kane, who returned at Burnley last weekend and also played midweek vs Chelsea, is set to start his third game inside a week.
Spurs hold a four-point cushion over their rivals, but that could be cut to one point, should they lose at Wembley.
Manchester United are five points back, with Chelsea two more behind, but Maurizio Sarri's side have a game in hand.
Lloris, Gazzaniga, Trippier, Alderweireld, Aurier, Sanchez, Rose, Walker-Peters, Sissoko, Foyth, Winks, Lucas, Eriksen, Skipp, Son, Lamela, Llorente, Kane
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