Paul Pogba looks set to leave the club despite being included in the club's preseason tour squad with agent Mino Raiola confirming he is currently "in the process" of negotiating a move away.
With that in mind Milinkovic-Savic has been suggested as a possible replacement with suggestions that United are at the front of any queue to sign him.
Reports in Italy on Sunday claim that United will open negotiations with Lazio with an offer of £67m.
The Italian club are in no hurry to sell, however, and could demand as much as £120m for the Serbian, a figure well within the budget for Ole Gunnar Solskjaer should he choose to spend it.
Harry Maguire could join him with a fee edging closer and closer to being agreed between United and Leicester.
The Sunday Mirror report that United are ready to pay £70m for him and include Marcos Rojo as a sweetener in the deal.
The Foxes are holding out for closer to £90m with any move likely to eclipse Virgil van Dijk's £75m move to Liverpool as the richest for a defender ever.
Manchester City are also keen but aren't willing to go that high leaving the way clear for United.
United have also reportedly agreed to meet Ajax's asking price for Matthijs de Ligt as the chase for his signature takes yet another twist.
The Dutch international looked all set to join Juventus but as the move continues to stall United have been buoyed by the opportunity to swoop in and steal him.
Ajax want £67m for their captain and United are more than willing to meet that figure, according to the Daily Express.
It remains to be seen whether De Ligt is willing to agree to a switch to Old Trafford, however.
Meanwhile, in a huge boost David de Gea is ready to end his contract holdout and sign a new deal with the club.
That's according to the Sunday Mirror.
They say he has agreed a new contract that will see him paid £350,000 per week making him the highest goalkeeper in the world.
United will make an opening offer Newcastle's Sean Longstaff this week
Solskjaer is particularly keen on the young midfielder and has sanctioned an opening bid in the region of £30million for the 21-year-old according to the Sunday Times.
It remains to be seen how much the Magpies hold out for having already lost manager Rafa Benitez and strikers Salomon Rondon and Ayoze Perez this summer.
There could be worse news over Real Betis' Giovani Lo Celso, however, with Tottenham apparently edging ahead in the race to sign him.
The Argentine international is firmly on Mauricio Pochettino's radar as he looks to reshape his Champions League finalists.
And Football Insider claim that the club are ready to back their manager with an offer of more than £60m for Lo Celso with a £150,000-a-week contract that could trump United.
Elsewhere, United have been boosted in their attempts to sign Bruno Fernandes.
The Portuguese international is available this summer after starring last season with Sporting ready to cash in on their sought-after midfielder.
Fernandes has an £88m clause in his current contract but reports in Portugal suggest that Sporting would take far less to complete a deal.
They say club president Frederico Varandas would instead would be ready to sell for £53m which represents a huge step forward in negotiations.
Inter are pushing ahead with plans to sign Romelu Lukaku, who is Antonio Conte's first choice to replace Mauro Icardi, with the Italian ready to ditch the Argentine forward.
As well as Lukaku they also want Nemanja Matic, according to ESPN, with the Serbian midfielder having requested to speak with the club about their plans for him.
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